Evidence map›Paper›PMID 37983304›Full record

ArticleEpigenetics2023

Epigenetic age acceleration, neonatal morbidities, and neurobehavioral profiles in infants born very preterm.

Uriel Paniagua, Barry M Lester, Carmen J Marsit, Marie Camerota, Brian S Carter, Jennifer F Check, Jennifer Helderman, Julie A Hofheimer, Elisabeth C McGowan, Charles R Neal and 6 more

Open access · diamondAbstract read
In one paragraph

Article in Epigenetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 1 country.

Uriel PaniaguaDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Barry M LesterDepartment of Pediatrics, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, USA.
Carmen J MarsitDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Marie CamerotaBrown Center for the Study of Children at Risk, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, USA.
Brian S CarterDepartment of Pediatrics-Neonatology, Children's Mercy Hospital, Kansas City, MO, USA.
Jennifer F CheckDepartment of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jennifer HeldermanDepartment of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Julie A HofheimerDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Elisabeth C McGowanDepartment of Pediatrics, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, USA.
Charles R NealDepartment of Pediatrics, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA.
Steven L PastyrnakDepartment of Pediatrics, Corewell Health, Helen DeVos Children's Hospital, Grand Rapids, MI, USA.
Lynne M SmithDepartment of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
Sheri A DellaGrottaBrown Center for the Study of Children at Risk, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, USA.
Lynne M DansereauBrown Center for the Study of Children at Risk, Brown Alpert Medical School and Women and Infants Hospital, Providence, RI, USA.
T Michael O'SheaDepartment of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Todd M EversonDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA.ORCID 0000-0003-2732-4550
Emory University · USProvidence College · USUniversity of North Carolina at Chapel Hill · USWake Forest University · USBrown University · USChildren's Mercy Hospital · USHelen DeVos Children's Hospital · USUCLA Medical Center · USUniversity of Hawaiʻi at Mānoa · US

Funding

Epigenetic Predictors of Impairment in Very Preterm InfantsR01HD084515 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI EVERSON, TODD M, LESTER, BARRY M. · 2016 to 2023
$3.9M
Neonatal Neurobehavior and Outcomes in Very Preterm InfantsR01HD072267 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M., O'SHEA, MICHAEL · 2013 to 2017
$3.3M
NICHD NIH HHS R01 HD072267NICHD NIH HHS R01 HD084515
6 · The paper itself

Abstract

Epigenetic age acceleration is a risk factor for chronic diseases of ageing and may reflect aspects of biological ageing. However, few studies have examined epigenetic ageing during the early neonatal period in preterm infants, who are at heightened risk of developmental problems. We examined relationships between neonatal age acceleration, neonatal morbidities, and neurobehavioral domains among very preterm (<30 weeks gestation) infants to characterize whether infants with early morbidities or different neurobehavioral characteristics had accelerated or decelerated epigenetic ageing. This study uses data from the Neonatal Neurobehavior and Outcomes in Very Preterm Infants (NOVI) study, restricted to infants with data on variables assessed (

Indexed as

Bronchopulmonary DysplasiaInfant, Premature, DiseasesDNA MethylationEpigenesis, GeneticGestational AgeHumansInfantInfant, Extremely PrematureInfant, NewbornMorbidityepigenetic clockNeonatal ageingneonatal morbidityneurobehaviorpreterm infants

Identifiers

PMID37983304
PMCPMC10732637
OpenAlexW4388822064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.