ArticlePLoS biology2023
Item-specific neural representations during human sleep support long-term memory.
Article in PLoS biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Efficacy and mechanisms of repeated closed-loop auditory exposure during slow-wave sleep for internet gaming disorder.Molecular psychiatry · 2025Trial
- Sleep strengthens successor representations of learned sequences in humans.PLoS biology · 2026Article
- The effects of targeted reactivation on memories cued once or multiple times during a nap.Neuropsychologia · 2025Article
- Slow-wave sleep and REM sleep differentially contribute to memory representational transformation.Communications biology · 2025Article
- Article
- Personalized targeted memory reactivation enhances consolidation of challenging memories via slow wave and spindle dynamics.NPJ science of learning · 2025Article
- Electrophysiological signatures underlying variability in human memory consolidation.Nature communications · 2025Article
- Selective Modulation of Fear Memory in Non-Rapid Eye Movement Sleep.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Aversive memories can be weakened during human sleep via the reactivation of positive interfering memories.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Reactivating cue approached positive personality traits during sleep promotes positive self-referential processing.iScience · 2024Article
- Modulating social learning-induced evaluation updating during human sleep.NPJ science of learning · 2024Article
- Memory Reactivation during Sleep Does Not Act Holistically on Object Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Observing the suppression of individual aversive memories from conscious awareness.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Article
- Memory reactivation during sleep does not act holistically on object memory.bioRxiv : the preprint server for biology · 2024Article
- Neural reactivation during human sleep.Emerging topics in life sciences · 2023Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how individual memories are reactivated during sleep is essential in theorizing memory consolidation. Here, we employed the targeted memory reactivation (TMR) paradigm to unobtrusively replaying auditory memory cues during human participants' slow-wave sleep (SWS). Using representational similarity analysis (RSA) on cue-elicited electroencephalogram (EEG), we found temporally segregated and functionally distinct item-specific neural representations: the early post-cue EEG activity (within 0 to 2,000 ms) contained comparable item-specific representations for memory cues and control cues, signifying effective processing of auditory cues. Critically, the later EEG activity (2,500 to 2,960 ms) showed greater item-specific representations for post-sleep remembered items than for forgotten and control cues, indicating memory reprocessing. Moreover, these later item-specific neural representations were supported by concurrently increased spindles, particularly for items that had not been tested prior to sleep. These findings elucidated how external memory cues triggered item-specific neural representations during SWS and how such representations were linked to successful long-term memory. These results will benefit future research aiming to perturb specific memory episodes during sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.