Evidence map›Paper›PMID 37983027›Full record

ArticleJAMA network open2023

Survival of Patients With Head and Neck Merkel Cell Cancer: Findings From the Pan-Canadian Merkel Cell Cancer Collaborative.

Ameeta Lubina Nayak, Arthur Travis Pickett, Megan Delisle, Brittany Dingley, Ranjeeta Mallick, Trevor Hamilton, Heather Stuart, Martha Talbot, Gregory McKinnon, Evan Jost and 25 more

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in JAMA network open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors at 16 institutions in 1 country.

Ameeta Lubina NayakDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Arthur Travis PickettDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Megan DelisleDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Brittany DingleyDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Ranjeeta MallickDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Trevor HamiltonBC Cancer, Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Heather StuartBC Cancer, Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Martha TalbotBC Cancer, Department of Surgery, Vancouver General Hospital, Vancouver, British Columbia, Canada.
Gregory McKinnonDepartment of Surgery, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada.
Evan JostDepartment of Surgery, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada.
Eva ThiboutotDepartment of Surgery, Foothills Hospital, University of Calgary, Calgary, Alberta, Canada.
Valerie FrancescuttiDepartment of Surgery, Hamilton Health Sciences Center, McMaster University, Hamilton, Ontario, Canada.
Sal SammanDepartment of Surgery, Hamilton Health Sciences Center, McMaster University, Hamilton, Ontario, Canada.
Alexandra EassonDepartment of Surgery, Princess Margaret Hospital, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada.
Angela SchellenbergDepartment of Surgery, Princess Margaret Hospital, Mount Sinai Hospital and University Health Network, Toronto, Ontario, Canada.
Shaila MerchantDepartment of Surgery, Queen's University, Kingston, Ontario, Canada.
Julie LaDepartment of Surgery, Queen's University, Kingston, Ontario, Canada.
Kaitlin VanderbeckDepartment of Surgery, Queen's University, Kingston, Ontario, Canada.
Frances WrightDepartment of Surgery, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.
David Berger-RichardsonDepartment of Surgery, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada.
Pamela HebbardDepartment of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
Olivia HershornDepartment of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
Rami YounanDepartment of Surgery, Centre Hospitalier de L'Université de Montreal, Montreal, Quebec, Canada.
Erica PatocskaiDepartment of Surgery, Centre Hospitalier de L'Université de Montreal, Montreal, Quebec, Canada.
Samuel Rodriguez-QizilbashDepartment of Surgery, Centre Hospitalier de L'Université de Montreal, Montreal, Quebec, Canada.
Ari MeguerditichianDepartment of Surgery, McGill University Health Network, Montreal, Quebec, Canada.
Vanina TchuenteDepartment of Surgery, McGill University Health Network, Montreal, Quebec, Canada.
Suzanne KazandjianDepartment of Surgery, McGill University Health Network, Montreal, Quebec, Canada.
Alex MathiesonDepartment of Surgery, Memorial University, St-John's, Newfoundland, Canada.
Farisa HossainDepartment of Surgery, Memorial University, St-John's, Newfoundland, Canada.
Jessika HetuDepartment of Surgery, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Martin CorstenHead and Neck Surgery, Dalhousie University, Halifax, Nova Scotia, Canada.
Angelina TohméDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Carolyn NessimDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Stephanie Johnson-ObasekiDepartment of Surgery, The Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ontario, Canada.
Ottawa Hospital · CACentre Hospitalier de l’Université de Montréal · CAOttawa Hospital Research InstituteQueen's University · CAVancouver General Hospital · CAHamilton Health Sciences · CAMcGill University Health Centre · CAMemorial University of Newfoundland · CASunnybrook Health Science Centre · CAUniversity Health Network · CAUniversity of Calgary · CAUniversity of Manitoba · CADalhousie University · CAFoothills Medical Centre · CAPrincess Margaret Cancer Centre · CAUniversité de Sherbrooke · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma. Due to its relatively low incidence and limited prospective trials, current recommendations are guided by historical single-institution retrospective studies. Objective: To evaluate the overall survival (OS) of patients in Canada with head and neck MCC (HNMCC) according to American Joint Committee on Cancer 8th edition staging and treatment modalities. Design, Setting, and Participants: A retrospective cohort study of 400 patients with a diagnosis of HNMCC between July 1, 2000, and June 31, 2018, was conducted using the Pan-Canadian Merkel Cell Cancer Collaborative, a multicenter national registry of patients with MCC. Statistical analyses were performed from January to December 2022. Main Outcomes and Measures: The primary outcome was 5-year OS. Multivariable analysis using a Cox proportional hazards regression model was performed to identify factors associated with survival. Results: Between 2000 and 2018, 400 patients (234 men [58.5%]; mean [SD] age at diagnosis, 78.4 [10.5] years) with malignant neoplasms found in the face, scalp, neck, ear, eyelid, or lip received a diagnosis of HNMCC. At diagnosis, 188 patients (47.0%) had stage I disease. The most common treatment overall was surgery followed by radiotherapy (161 [40.3%]), although radiotherapy alone was most common for stage IV disease (15 of 23 [52.2%]). Five-year OS was 49.8% (95% CI, 40.7%-58.2%), 39.8% (95% CI, 26.2%-53.1%), 36.2% (95% CI, 25.2%-47.4%), and 18.5% (95% CI, 3.9%-41.5%) for stage I, II, III, and IV disease, respectively, and was highest among patients treated with surgery and radiotherapy (49.9% [95% CI, 39.9%-59.1%]). On multivariable analysis, patients treated with surgery and radiotherapy had greater OS compared with those treated with surgery alone (hazard ratio [HR], 0.76 [95% CI, 0.46-1.25]); however, this was not statistically significant. In comparison, patients who received no treatment had significantly worse OS (HR, 1.93 [95% CI, 1.26-2.96)]. Conclusions and Relevance: In this cohort study of the largest Canada-wide evaluation of HNMCC survival outcomes, stage and treatment modality were associated with survival. Multimodal treatment was associated with greater OS across all disease stages.

Indexed as

Carcinoma, Merkel CellHead and Neck NeoplasmsSkin NeoplasmsCanadaChildCohort StudiesHumansMaleProspective StudiesRadiotherapy, AdjuvantRetrospective Studies

Identifiers

PMID37983027
PMCPMC10660167
OpenAlexW4388834350

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.