Evidence map›Paper›PMID 37982973›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder-related optic neuritis.

Qinglin Yang, Chuntao Lai, Chao Meng, Qinglin Chang, Na Wei, Jiawei Wang

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Qinglin YangDepartment of Neurology of Beijing Tongren Hospital, Capital Medical University, Beijing, China. lin8082@sina.com.ORCID http://orcid.org/0000-0002-2198-0330
Chuntao LaiDepartment of Neurology of Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Chao MengDepartment of Neurology of Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Qinglin ChangDepartment of Radiology of Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Na WeiDepartment of Neurology of Xuanwu Hospital, Capital Medical University, Beijing, China.
Jiawei WangDepartment of Neurology of Beijing Tongren Hospital, Capital Medical University, Beijing, China.

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6 · The paper itself

Abstract

backgroundVery late-onset neuromyelitis optica spectrum disorder-related optic neuritis is limited to a few case reports.

objectiveTo investigate the clinical features and visual prognosis of very late-onset neuromyelitis optica spectrum disorder-related optic neuritis.

methodsThis study evaluated 22 patients with first-onset optic neuritis and fulfilled the 2015 diagnosis criteria for neuromyelitis optica spectrum disorders.

resultsThe mean age at optic neuritis onset was 73.91 ± 4.71 (range: 70-82) years with a female predominance (81.8%; ratio: 4.5:1). Antinuclear antibody seropositivity and seronegativity were identified in 12 (55.5%) and 10 (45.5%) patients, respectively. Severe visual loss persisted in 19 (19/42, 45.3%) eyes at the last follow-up. Although patients with antinuclear antibody seropositivity had a significantly higher frequency of attacks (P = 0.015), but they had a longer median time to reach severe visual loss (37 vs. 26 months; log-rank test, P = 0.023). Multivariate logistic regression analysis revealed antinuclear antibody seropositivity (hazard ratio = 4.849, 95% confidence interval: 1.309-17.965, P = 0.018) as a good predictor of visual acuity improvement.

conclusionPatients with very late-onset neuromyelitis optica spectrum disorder-related optic neuritis may develop severe optic neuritis, and those with antinuclear antibody seronegativity have a similar clinical presentation but worse outcome than those with seropositivity.

Indexed as

Neuromyelitis OpticaOptic NeuritisAgedAged, 80 and overAntibodies, AntinuclearAquaporin 4EyeFemaleHumansMalePrognosisRetrospective StudiesAntibodies, AntinuclearAquaporin 4Antinuclear antibodiesMagnetic resonance imagingNeuromyelitis optica spectrum disorderOptic neuritisVery late-onset

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PMID37982973

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