Evidence map›Paper›PMID 37982930›Full record

ArticleMolecular biology reports2023

Intra-articular site-specific distribution of advanced glycation end products in the shoulder of patients with diabetes mellitus having rotator cuff tears.

Tatsuo Kato, Issei Shinohara, Yutaka Mifune, Atsuyuki Inui, Hanako Nishimoto, Tomoya Yoshikawa, Takahiro Furukawa, Shuya Tanaka, Masaya Kusunose, Yuichi Hoshino and 2 more

Abstract read
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Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Nanozyme-Integrated Hydrogel Targeting AGEs for Diabetic Osteoarthritis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tatsuo Kato *Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Issei Shinohara *Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Yutaka MifuneDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan. m-ship@kf7.so-net.ne.jp.
Atsuyuki InuiDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Hanako NishimotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Tomoya YoshikawaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Takahiro FurukawaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Shuya TanakaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Masaya KusunoseDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Yuichi HoshinoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Takehiko MatsushitaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Ryosuke KurodaDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, 5-2, Kusunoki-cho7, Chuo-ku, Kobe-shi, 650-0017, Hyogo, Japan.
Kobe University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAdvanced glycation end products (AGEs) are compounds formed due to aging and diabetes mellitus (DM). They activate NADPH oxidase (NOX) by binding to their receptors, thereby increasing the production of reactive oxygen species (ROS), which cause oxidative stress. In this study, we investigated the effects of AGEs on the tissues of the shoulder joint (such as rotator cuff synovium, and capsule) in patients with DM having rotator cuff tears.

methodsThis study included eight patients with DM who underwent surgical treatment for rotator cuff tears with contracture. The rotator cuff, synovium, and joint capsule were harvested at the time of surgery and evaluated by hematoxylin-eosin staining. Furthermore, immunostaining was used for evaluating AGEs and receptor for AGEs (RAGE), cell activity, ROS, and apoptosis. Quantitative real-time polymerase chain reaction (qPCR) was employed for the cellular evaluation of NOX, interleukins, RAGE, and collagen.

resultsThe AGEs and RAGE staining as well as the ratio of ROS and apoptosis were in the following order: rotator cuff > joint capsule > synovium. In contrast, the cellular activity was significantly higher in the synovium than in the other regions. The type I collagen expression (as shown by qPCR) as well as the RAGE and NOX expressions were as follows: rotator cuff > joint capsule > synovium. Conversely, the expression of inflammatory cytokines (i.e., IL-6 and IL-1β) was higher in the synovium than in the other regions.

conclusionsOur study is among the first to evaluate the effects of AGEs on each tissue of the shoulder joint in patients with DM having rotator cuff tears and contractures. The accumulation of AGEs in each tissue of the shoulder joint could reveal the locations affected by DM, which can lead to a better understanding of the pathophysiology of DM-related shoulder diseases.

Indexed as

ContractureDiabetes MellitusRotator Cuff InjuriesGlycation End Products, AdvancedHumansReactive Oxygen SpeciesRotator CuffGlycation End Products, AdvancedReactive Oxygen SpeciesAdvanced glycation end productsCell viabilityDiabetes mellitusReactive oxygen speciesRotator cuff tearsShoulder capsuleSynovium

Identifiers

PMID37982930
OpenAlexW4388834442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.