Evidence map›Paper›PMID 37982893›Full record

ArticlePediatric surgery international2023

A novel mouse model of intestinal neuronal dysplasia: visualization of the enteric nervous system.

Naho Fujiwara, Katsumi Miyahara, Dorothy Lee, Nana Nakazawa-Tanaka, Chihiro Akazawa, Masahiko Hatano, Agostino Pierro, Atsuyuki Yamataka

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Naho FujiwaraDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. naho@juntendo.ac.jp.
Katsumi MiyaharaLaboratory of Morphology and Image Analysis, Biomedical Research Core Facilities, Juntendo University School of Medicine, Tokyo, Japan.
Dorothy LeeDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Canada.
Nana Nakazawa-TanakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Chihiro AkazawaIntractable Disease Research Center, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan.
Masahiko HatanoDepartment Biomedical Science, Chiba University Graduate School of Medicine, Chiba, Japan.
Agostino PierroDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, Canada.
Atsuyuki YamatakaDepartment of Pediatric General and Urogenital Surgery, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Juntendo University · JPHospital for Sick Children · CAChiba University · JP

Funding

JSPS KAKENHI 22K08721
6 · The paper itself

Abstract

purposeIntestinal neuronal dysplasia (IND) is a congenital anomaly affecting gastrointestinal neural innervation, but the pathogenesis remains unclear. The homozygous Ncx/Hox11L.1 knockout (Ncx

methodsSox10-Venus

resultsNcx

conclusionThis study has established a reliable animal model that exhibits characteristics similar to patients with IND. This novel mouse model can allow the easy visualization of ENS in a time- and cost-effective way to study the pathogenesis of IND.

Indexed as

Enteric Nervous SystemHirschsprung DiseaseAnimalsBody WeightColonHumansIntestinesMiceMice, TransgenicNeural CrestEnteric nervous systemHomozygous mutant of NcxIntestinal neuronal dysplasiaSox10

Identifiers

PMID37982893
OpenAlexW4388824407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.