Evidence map›Paper›PMID 37982872›Full record

ArticleCell and tissue research2024

Distribution, quantification, and characterization of substance P enteric neurons in the submucosal and myenteric plexuses of the porcine colon.

Maurizio Mazzoni, Luis Cabanillas, Anna Costanzini, Filippo Caremoli, Mulugeta Million, Muriel Larauche, Paolo Clavenzani, Roberto De Giorgio, Catia Sternini

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell and tissue research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Maurizio Mazzoni *Department of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, 40064, Bologna, Italy.
Luis Cabanillas *Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Anna CostanziniDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Filippo CaremoliDivision of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Mulugeta MillionDivision of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Muriel LaraucheDivision of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA.
Paolo ClavenzaniDepartment of Veterinary Medical Sciences, University of Bologna, Ozzano Emilia, 40064, Bologna, Italy.
Roberto De GiorgioDepartment of Translational Medicine, University of Ferrara, Ferrara, Italy.
Catia SterniniDivision of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA, 90095, USA. csternin@ucla.edu.ORCID http://orcid.org/0000-0003-0492-1993
University of California, Los Angeles · USUniversity of Bologna · ITUniversity of Ferrara · ITVita-Salute San Raffaele University · IT

Funding

Pilot and Feasibility ProgramP30DK041301 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROZENGURT, JUAN ENRIQUE · 1990 to 2019
$18.0M
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous SystemOT2OD024899 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION, TACHE, YVETTE FRANCE · 2017 to 2021
$13.1M
Structural and functional mapping of visceral pain afferent neurocircuitries of the colorectum and bladder in preclinical modelsU01NS113871 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION · 2019 to 2021
$2.1M
NIDDK NIH HHS P30 DK041301NIH HHS OT2 OD024899NINDS NIH HHS U01 NS113871
6 · The paper itself

Abstract

The pig is an important translational model for studying intestinal physiology and disorders for its many homologies with humans, including the organization of the enteric nervous system (ENS), the major regulator of gastrointestinal functions. This study focused on the quantification and neurochemical characterization of substance P (SP) neurons in the pig ascending (AC) and descending colon (DC) in wholemount preparations of the inner submucosal plexus (ISP), outer submucosal plexus (OSP), and myenteric plexus (MP). We used antibodies for the pan-neuronal marker HuCD, and choline acetyltransferase (ChAT) and neuronal nitric oxide synthase (nNOS), markers for excitatory and inhibitory transmitters, for multiple labeling immunofluorescence and high-resolution confocal microscopy. The highest density of SP immunoreactive (IR) neurons was in the ISP (222/mm

Indexed as

Myenteric PlexusSubmucous PlexusAnimalsCholine O-AcetyltransferaseColonHumansNeuronsSubstance PSwineCholine O-AcetyltransferaseSubstance PCholinergic and nitrergic transmissionExcitatory motor neuronsInhibitory motor neuronsInterneuronsSecretomotor neurons

Identifiers

PMID37982872
PMCPMC10774220
OpenAlexW4388828298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.