ArticleEuropean radiology2024
Long-term pulmonary outcome of children with congenital diaphragmatic hernia: functional lung MRI using matrix-pencil decomposition enables side-specific assessment of lung function.
Article in European radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Non-contrast enhanced functional lung MRI in children: systematic review.Frontiers in pediatrics · 2025Pooled it
- Adapted Linear Binning Method to Assess Pulmonary Ventilation and Perfusion in Children Using Lung Matrix Pencil Decomposition (MP)-MRI.Magnetic resonance in medicine · 2026Article
- Estimating pediatric lung volumetric parameters via rapid, limited-slice, free-breathing thoracic dynamic MRI.Medical physics · 2026Article
- Functional patterns of healthy human respiratory dynamics by 3D MR spirometry.European radiology · 2026Article
- Magnetic Resonance Imaging in the Clinical Evaluation of Lung Disorders: Current Status and Future Prospects.Journal of magnetic resonance imaging : JMRI · 2025Review
- An automated pipeline for computation and analysis of functional ventilation and perfusion lung MRI with matrix pencil decomposition: TrueLung.Zeitschrift fur medizinische Physik · 2025Article
- Quantifying Spatial Distribution of Ventilation Defects in Multiple Pulmonary Diseases With HyperpolarizedJournal of magnetic resonance imaging : JMRI · 2025Article
- Non-contrast enhanced functional lung MRI in children: report on 900 own measurements using matrix-pencil decomposition (MP-) MRI.Frontiers in pediatrics · 2025Article
- Pulmonary Morbidity in Congenital Diaphragmatic Hernia Survivors Treated at a Non-ECMO Center From 1998 to 2015: A Cross-Sectional Study.Pediatric pulmonology · 2025Article
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Authors and funding
13 authors at 3 institutions in 1 country.
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Abstract
objectivesIn patients with congenital diaphragmatic hernia (CDH) the exact functional outcome of the affected lung side is still unknown, mainly due to the lack of spatially resolved diagnostic tools. Functional matrix-pencil decomposition (MP-) lung MRI fills this gap as it measures side-specific ventilation and perfusion. We aimed to assess the overall and side-specific pulmonary long-term outcomes of patients with CDH using lung function tests and MP-MRI.
methodsThirteen school-aged children with CDH (seven with small and six with large defect-sized CDH, defined as > 50% of the chest wall circumference being devoid of diaphragm tissue) and thirteen healthy matched controls underwent spirometry, multiple-breath washout, and MP-MRI. The main outcomes were forced expiratory volume in 1 second (FEV
resultsPatients with a large CDH showed significantly reduced overall lung function compared to healthy controls (mean difference [95%-CI
conclusionsData indicate impaired overall lung function with particular limitation of the ipsilateral side in patients with a large CDH. MP-MRI is a promising tool to provide valuable side-specific functional information in the follow-up of patients with CDH. CLINICAL RELEVANCE STATEMENT: In patients with congenital diaphragmatic hernia, easily applicable MP-MRI allows specific examination of the lung side affected by the hernia and provides valuable information on ventilation and perfusion with implications for clinical practice, making it a promising tool for routine follow-up. KEY POINTS: • Functional matrix pencil decomposition (MP) MRI data from a small sample indicate reduced ipsilateral pulmonary ventilation and perfusion in children with large congenital diaphragmatic hernia (CDH). • Easily applicable pencil decomposition MRI provides valuable side-specific diagnostic information on lung ventilation and perfusion. This is a clear advantage over conventional lung function tests, helping to comprehensively follow up patients with congenital diaphragmatic hernia and monitor therapy effects.
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