Evidence map›Paper›PMID 37982803›Full record

ArticleACS applied materials & interfaces2023

Particle ID: A Multiplexed Hydrogel Bead Platform for Biomedical Applications.

Lokman Alpsoy, Abanoub Selim Sedeky, Ulrike Rehbein, Kathrin Thedieck, Thomas Brandstetter, Jürgen Rühe

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lokman AlpsoyDepartment of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, Freiburg im Breisgau 79110, Germany.ORCID 0000-0002-3524-9485
Abanoub Selim SedekyDepartment of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, Freiburg im Breisgau 79110, Germany.
Ulrike RehbeinInstitute of Biochemistry, Center of Chemistry and Biomedicine, University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-9104-4222
Kathrin ThedieckInstitute of Biochemistry, Center of Chemistry and Biomedicine, University of Innsbruck, 6020 Innsbruck, Austria.ORCID 0000-0002-9069-2930
Thomas BrandstetterDepartment of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, Freiburg im Breisgau 79110, Germany.ORCID 0000-0002-3991-8295
Jürgen RüheDepartment of Microsystems Engineering (IMTEK), Chemistry & Physics of Interfaces, University of Freiburg, Freiburg im Breisgau 79110, Germany.ORCID 0000-0002-2534-8228

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a new platform based on hydrogel beads for multiplex analysis that can be fabricated, barcoded, and functionalized in a single step using a simple microfluidic assembly and a photo-cross-linking process. The beads are generated in a two-phase flow fluidic system and photo-cross-linking of the polymer in the aqueous phase by C,H insertion cross-linking (CHic). The size and shape of the hydrogel particles can be controlled over a wide range by fluidic parameters. During the fabrication of the beads, they are barcoded by using physical and optical barcoding strategies. Magnetic beads and fluorescent particles, which allow identification of the production batch number, are added simultaneously as desired, resulting in complex, multifunctional beads in a one-step reaction. As an example of biofunctionalization,

Indexed as

HydrogelsEnzyme-Linked Immunosorbent AssayHumansHydrogels3D bead-based immunoassaybarcoding of beadsbiofunctionalization of beadsborelliosishydrogel beadsmultiplexing

Identifiers

PMID37982803
PMCPMC10712431

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.