Evidence map›Paper›PMID 37982491›Full record

ArticleThe American Journal of dermatopathology2024

Round Bodies Detected by Treponema pallidum Immunohistochemical Stain in Two Cases of Cutaneous Syphilitic Gummata.

Suzanne W Birmingham, Lina Saeed, Charles M Thurlow, Kendra Vilfort, Allan Pillay, Nathan W Rojek, Linda T Doan, Bonnie A Lee

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The American Journal of dermatopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Suzanne W BirminghamDepartment of Dermatology, University of California, Irvine, Irvine, CA; and.ORCID 0000-0003-0169-9813
Lina SaeedDepartment of Dermatology, University of California, Irvine, Irvine, CA; and.
Charles M ThurlowDivision of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Kendra VilfortDivision of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Allan PillayDivision of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA.
Nathan W RojekDepartment of Dermatology, University of California, Irvine, Irvine, CA; and.
Linda T DoanDepartment of Dermatology, University of California, Irvine, Irvine, CA; and.
Bonnie A LeeDepartment of Dermatology, University of California, Irvine, Irvine, CA; and.
University of California, Irvine · USCenters for Disease Control and Prevention · US

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

abstractTertiary syphilis may present a diagnostic challenge due to negative nontreponemal serologies in up to 30% of cases and frequent lack of identifiable spirochetes on histopathology or other direct detection tests. We report 2 cases of round bodies staining with Treponema pallidum immunohistochemistry by light microscopy in biopsies from cutaneous syphilitic gummata. In 1 case, the finding was validated 3 times by 2 independent laboratories; in the other case, T. pallidum was detected by polymerase chain reaction in the biopsy sample. Spirochete round bodies have previously been reported in the setting of electron microscopy and fluorography, but to the best of our knowledge, have not been reported by light microscopy in a routine skin biopsy. Although the clinical implications are unclear, this may represent a helpful new paradigm for the diagnosis of tertiary syphilis.

Indexed as

SyphilisSyphilis, CutaneousColoring AgentsHumansTreponema pallidumColoring Agents

Identifiers

PMID37982491
PMCPMC11465137
OpenAlexW4388826401

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.