Evidence map›Paper›PMID 37982489›Full record

ArticleeLife2023

Differential regulation of hair cell actin cytoskeleton mediated by SRF and MRTFB.

Ling-Yun Zhou, Chen-Xi Jin, Wen-Xiao Wang, Lei Song, Jung-Bum Shin, Ting-Ting Du, Hao Wu

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ling-Yun ZhouDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0009-0001-7041-4730
Chen-Xi JinDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wen-Xiao WangDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lei SongDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jung-Bum ShinDepartment of Neuroscience, University of Virginia, Charlottesville, United States.ORCID https://orcid.org/0000-0003-3047-0874
Ting-Ting Du *Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-0333-8739
Hao Wu *Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-5317-902X
Shanghai Jiao Tong University · CNUniversity of Virginia · US

Funding

Fundamental Research Program Funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong university School of Medicine JYZZ057National Natural Science Foundation of China 81970872National Natural Science Foundation of China 82000975School of Medicine, Shanghai Jiao Tong University JYZZ057Science and Technology Commission of Shanghai Municipality 21JC1404000Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases 14DZ2260300Shanghai Municipal Science and Technology Major Project 21JC1404000
6 · The paper itself

Abstract

The MRTF-SRF pathway has been extensively studied for its crucial role in driving the expression of a large number of genes involved in actin cytoskeleton of various cell types. However, the specific contribution of MRTF-SRF in hair cells remains unknown. In this study, we showed that hair cell-specific deletion of

Indexed as

Actin CytoskeletonHair Cells, AuditoryActinsGene Expression RegulationStereociliaActinscell biologycochleahair cellinner earmouse

Identifiers

PMID37982489
PMCPMC10703445
OpenAlexW4388826926

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.