Evidence map›Paper›PMID 37981665›Full record

Trial reportBMC oral health2023

Efficacy of curcumin gel as an adjunct to scaling and root planing on salivary procalcitonin level in the treatment of patients with chronic periodontitis: a randomized controlled clinical trial.

Reham Abdel-Fatah, Bassant Mowafey, Azza Baiomy, Samah Elmeadawy

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05667376 (Efficacy of Curcumin Gel as an Adjunct to Scaling and Root Planing on Salivary Procalcitonin Level in the Treatment of Periodontitis Patients), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05667376 nacompletednot on this map

Efficacy of Curcumin Gel as an Adjunct to Scaling and Root Planing on Salivary Procalcitonin Level in the Treatment of Periodontitis Patients: Randomized Controlled Clinical Trial

TypeinterventionalSponsorReham abdelfatahRan2021 to 2021Enrolled54ConditionsPeriodontitisArmsLocal drug delivery, curcumin gel
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Role of curcumin in oral infection and inflammation.GMS hygiene and infection control · 2025
    Review
  14. Article
  15. Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Reham Abdel-FatahOral Medicine, Periodontology, Diagnosis, and Oral Radiology Department, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt. rehammohamed230@mans.edu.eg.
Bassant MowafeyOral Medicine, Periodontology, Diagnosis, and Oral Radiology Department, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt.
Azza BaiomyClinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Samah ElmeadawyOral Medicine, Periodontology, Diagnosis, and Oral Radiology Department, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt.
Mansoura University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

the aim of the studyTo evaluate the effect of curcumin gel combined with scaling and root planing (SRP) on salivary procalcitonin in periodontitis treatment. MATERIALS AND

methodsseventy patients were selected from the Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, and sixteen patients were excluded. Patients in groups II and III included stage II grade A periodontitis. The participants were classified into three groups: group I as a negative control group (individuals with healthy gingiva), group II (SRP) were treated with SRP, and group III (curcumin gel) which was applied weekly for four weeks after SRP. Clinical indices (plaque index (PI), gingival index (GI), clinical attachment level (CAL), and probing depth (PD)) and saliva samples for procalcitonin (PCT) assessment using an enzyme-linked immunosorbent assay (ELISA) test were collected and measured at both baselines and after six weeks.

resultsThis randomized controlled clinical trial registered on ClinicalTrials.gov (NCT05667376) and first posted at 28/12/2022 included Fifty-four patients (20 male; 34 female). Regarding the age and sex distribution, there was no statistically significant difference between the three studied groups (p > 0.05). There was no significant statistical difference regarding PI, GI, PPD, and CAL between group II and group III at baseline p (> 0.05). However, there was a significant statistical difference regarding the clinical parameters at baseline of both group II and group III as compared to group I (p ≤ 0.05). At six weeks after treatment, group III showed greater improvement in the PI, PD, and CAL as opposed to group II (p ≤ 0.05). Regarding PCT values, at baseline, there wasn't a statistically significant difference between group II and group III (p > 0.05). However, there was a significant statistical difference between group II, group III, and group I (p ≤ 0.05). At six weeks after treatment, there was a statistically significant decrease in PCT levels of both group II and III (p ≤ 0.05).

conclusionThe application of curcumin gel was found to have a significant effect on all clinical indices as opposed to SRP.

Indexed as

Chronic PeriodontitisCurcuminDental ScalingFemaleHumansMaleProcalcitoninRoot PlaningCurcuminProcalcitoninChronic periodontitisCurcuminProcalcitoninRandomized controlled clinical trialRoot planingScaling

Identifiers

PMID37981665
PMCPMC10658924
OpenAlexW4388809987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.