Evidence map›Paper›PMID 37981592›Full record

ArticleCellular and molecular life sciences : CMLS2023

Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of α-synuclein through deubiquitination.

Shouhai Wu, Tongxiang Lin, Yang Xu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Frontiers in molecular neuroscience · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shouhai WuState Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Tongxiang LinCenter for Regenerative and Translational Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Yang XuDepartment of Cardiology, Cardiovascular Key Lab of Zhejiang Province, State Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang, China. xuyang2020@zju.edu.cn.ORCID http://orcid.org/0000-0001-5574-921X
Guangzhou University of Chinese Medicine · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

Guangdong Science and Technology Department 2020A1515110450Key Research and Development Program of Zhejiang Province 2022C03006National Key Research and Development Program of China 2022YFC3401600the Fundamental Research Funds for the Central Universities 2021FZZX001-42the National Natural Science Foundation of China 81930084the National Natural Science Foundation of China 82230102Traditional Chinese Medicine Bureau Of Guangdong Province of China 20211183
6 · The paper itself

Abstract

Parkinson's disease (PD) is one of the most common neuro-degenerative diseases characterized by α-synuclein accumulation and degeneration of dopaminergic neurons. Employing genome-wide sequencing, we identified a polymorphic USP8 allele (USP8

Indexed as

Parkinson DiseaseAllelesalpha-SynucleinDopaminergic NeuronsEndopeptidasesEndosomal Sorting Complexes Required for TransportHumansUbiquitin Thiolesterasealpha-SynucleinEndopeptidasesEndosomal Sorting Complexes Required for TransportUbiquitin ThiolesteraseUSP8 protein, humanCRISPR/Cas9Disease predictionProtein structureRs3743044

Identifiers

PMID37981592
PMCPMC11072815
OpenAlexW4388807836

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.