Evidence map›Paper›PMID 37981468›Full record

ReviewImmunological investigations2024

Emerging Role of Astrocyte-Derived Extracellular Vesicles as Active Participants in CNS Neuroimmune Responses.

Pearl A Sutter, Erica R Lavoie, Evan T Lombardo, Meghan K Pinter, Stephen J Crocker

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunological investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pearl A SutterDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Erica R LavoieDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Evan T LombardoDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Meghan K PinterDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, USA.
Stephen J CrockerDepartment of Neuroscience, University of Connecticut School of Medicine, Farmington, Connecticut, USA.

Funding

Role of CD8 T cell-mediated Pathology in Globoid Cell LeukodystrophyR01NS131327 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Stephen J Crocker · 2023 to 2026
$2.0M
Regulation of Microgliosis in Globoid Cell LeukodystrophyR56NS099359 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CROCKER, STEPHEN J · 2017 to 2017
$574k
The Contribution of Central Nervous System Demyelination to Bladder DysfuntionR21NS125332 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI CROCKER, STEPHEN J, IMITOLA, JAIME · 2021 to 2021
$451k
The role of microglia as antigen presenting cells in Globoid Cell LeukodystrophyF30NS129238 · NINDS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SUTTER, PEARL A · 2022 to 2025
$195k
NINDS NIH HHS F30 NS129238NINDS NIH HHS R01 NS131327NINDS NIH HHS R21 NS125332NINDS NIH HHS R56 NS099359
6 · The paper itself

Abstract

Astrocyte-derived extracellular vesicles (ADEVs) have garnered attention as a fundamental mechanism of intercellular communication in health and disease. In the context of neurological diseases, for which prodromal diagnosis would be advantageous, ADEVs are also being explored for their potential utility as biomarkers. In this review, we provide the current state of data supporting our understanding on the manifold roles of ADEVs in several common neurological disorders. We also discuss these findings from a unique emerging perspective that ADEVs represent a means by which the central nervous system may broadcast influence over other systems in the body to affect neuroinflammatory processes, with both dual potential to either propagate illness or restore health and homeostasis.

Indexed as

AstrocytesExtracellular VesiclesBiomarkersCell CommunicationHumansBiomarkersAlzheimer’samyotrophic lateral sclerosisastrocytesmultiple sclerosisParkinson’s

Identifiers

PMID37981468
PMCPMC11472422

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.