ArticleBiological psychiatry2024
Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.
Article in Biological psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 31 citations in OpenAlex.
- MRI Correlates of Depression and Anxiety in Multiple Sclerosis.Diseases (Basel, Switzerland) · 2026Review
- Presence and Impact of Fatigue in Patients With Multiple Sclerosis.Medical science monitor : international medical journal of experimental and clinical research · 2026Observational
- Depression as a Disease of White Matter Network Disruption: Learning From Multiple Sclerosis.Biological psychiatry · 2026Review
- Dynamic Triangulation of Resting-State Networks and CSF Metabolites Reveals Bidirectional Causal Pathways in Multiple Sclerosis: A Mendelian Randomization Analysis.Journal of molecular neuroscience : MN · 2026Article
- Relationship status and the neurobehavioral symptoms of multiple sclerosis: a cross-sectional analysis.Journal of neurology · 2026Article
- Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- C-Reactive Protein and Neurological Autoimmune Diseases: Bridging the Diagnostic and Pathogenic Gap.International journal of molecular sciences · 2026Review
- From Billing Codes to Breakthroughs: Filtering Signal From Noise in Electronic Medical Records-Based Research.The Journal of neuropsychiatry and clinical neurosciences · 2026Article
- Affective reserve in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2025Article
- Understanding Depression in People Living with Multiple Sclerosis: A Narrative Review of Recent Literature.Neurology and therapy · 2025Review
- Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol.BMJ open · 2025Article
- Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis.JAMA network open · 2025Article
- Conventional MRI-Based Structural Disconnection and Morphometric Similarity Networks and Their Clinical Correlates in Multiple Sclerosis.Neurology · 2025Article
- Disease-Modifying Symptomatic Treatment (DMST): The Potential Role of Vortioxetine in the Treatment of Depression in Patients with Multiple Sclerosis.Current neuropharmacology · 2025Review
- Automated segmentation of multiple sclerosis lesions, paramagnetic rims, and central vein sign on MRI provides reliable diagnostic biomarkers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.Brain : a journal of neurology · 2024Article
- Dysphagia assessment in patients with multiple sclerosis - an additional piece to disability burden.Annals of clinical and translational neurology · 2024Article
- Association of Anxiety with Uncinate Fasciculus Lesion Burden in Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2024Article
- Investigating Mood and Cognition in People with Multiple Sclerosis: A Prospective Study Protocol.medRxiv : the preprint server for health sciences · 2024Article
- Human-derived monoclonal autoantibodies as interrogators of cellular proteotypes in the brain.Trends in neurosciences · 2024Review
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundMultiple sclerosis (MS) is an immune-mediated neurological disorder, and up to 50% of patients experience depression. We investigated how white matter network disruption is related to depression in MS.
methodsUsing electronic health records, 380 participants with MS were identified. Depressed individuals (MS+Depression group; n = 232) included persons who had an ICD-10 depression diagnosis, had a prescription for antidepressant medication, or screened positive via Patient Health Questionnaire (PHQ)-2 or PHQ-9. Age- and sex-matched nondepressed individuals with MS (MS-Depression group; n = 148) included persons who had no prior depression diagnosis, had no psychiatric medication prescriptions, and were asymptomatic on PHQ-2 or PHQ-9. Research-quality 3T structural magnetic resonance imaging was obtained as part of routine care. We first evaluated whether lesions were preferentially located within the depression network compared with other brain regions. Next, we examined if MS+Depression patients had greater lesion burden and if this was driven by lesions in the depression network. Primary outcome measures were the burden of lesions (e.g., impacted fascicles) within a network and across the brain.
resultsMS lesions preferentially affected fascicles within versus outside the depression network (β = 0.09, 95% CI = 0.08 to 0.10, p < .001). MS+Depression patients had more lesion burden (β = 0.06, 95% CI = 0.01 to 0.10, p = .015); this was driven by lesions within the depression network (β = 0.02, 95% CI = 0.003 to 0.040, p = .020).
conclusionsWe demonstrated that lesion location and burden may contribute to depression comorbidity in MS. MS lesions disproportionately impacted fascicles in the depression network. MS+Depression patients had more disease than MS-Depression patients, which was driven by disease within the depression network. Future studies relating lesion location to personalized depression interventions are warranted.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.