Evidence map›Paper›PMID 37980801›Full record

Trial reportJournal of anxiety disorders2023

Benchmarking secondary outcomes to posttraumatic stress disorder symptom change in response to cognitive processing and written exposure therapy for posttraumatic stress disorder.

Sarah A Stoycos, Casey L Straud, Ian H Stanley, Brian P Marx, Patricia A Resick, Stacey Young-McCaughan, Alan L Peterson, Denise M Sloan, STRONG STAR Consortium

Abstract readEquivalence TrialRandomized Controlled Trial
In one paragraph

Trial report in Journal of anxiety disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sarah A StoycosBehavioral Science Division, National Center for PTSD, VA Boston Healthcare System, United States; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, United States.
Casey L StraudDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, United States; Research and Development Service, South Texas Veterans Health Care System, United States; Department of Psychology, University of Texas at San Antonio, United States.
Ian H StanleyDepartment of Emergency Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, United States; Center for COMBAT Research, University of Colorado Anschutz Medical Campus, United States.
Brian P MarxBehavioral Science Division, National Center for PTSD, VA Boston Healthcare System, United States; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, United States.
Patricia A ResickDepartment of Psychiatry and Behavioral Sciences, Duke Health, United States.
Stacey Young-McCaughanDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, United States; Research and Development Service, South Texas Veterans Health Care System, United States.
Alan L PetersonDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at San Antonio, United States; Research and Development Service, South Texas Veterans Health Care System, United States; Department of Psychology, University of Texas at San Antonio, United States.
Denise M SloanBehavioral Science Division, National Center for PTSD, VA Boston Healthcare System, United States; Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, United States. Electronic address: denise.sloan@va.gov.
STRONG STAR Consortium

Funding

Postdoctoral Training Program in Stress and TraumaT32MH019836 · NIMH · TUFTS UNIVERSITY BOSTON · PI DENISE M. SLOAN · 1996 to 2026
$4.7M
NIMH NIH HHS T32 MH019836
6 · The paper itself

Abstract

Posttraumatic stress disorder (PTSD) has high comorbidity with other psychiatric conditions, including depression, generalized anxiety, and suicidality. Evidence-based treatments (EBTs) for PTSD are effective at reducing PTSD symptoms. However, evidence on the impact of PTSD EBTs on comorbid conditions is mixed and often uses pre-post analyses, which disregards PTSD symptom response. This study replicated and extended prior work on benchmarking quality of life to PTSD symptom response to a broader range of secondary outcomes using a research-based metric of clinically meaningful PTSD symptom change. Ninety-five active duty military members seeking treatment for PTSD participated in a randomized noninferiority trial examining two cognitive behavioral therapies for PTSD: Written Exposure Therapy and Cognitive Processing Therapy. Participants completed clinician-administered and self-rating assessments at baseline and 10 weeks post-first treatment session and were classified as PTSD treatment responders or nonresponders. Data were analyzed using generalized linear mixed effects models with repeated measures with fixed effects of time and PTSD symptom response category. PTSD treatment responders experienced significant improvements in secondary outcomes; nonresponders demonstrated statistically significant, but not clinically meaningful, comorbid symptom change. Our findings provide evidence that successfully treating PTSD symptoms may also positively impact psychiatric comorbidity.

Indexed as

Implosive TherapyStress Disorders, Post-TraumaticBenchmarkingCognitionHumansQuality of LifeAnxietyCognitive behavior therapyDepressionMilitary service membersPosttraumatic stress disorder

Identifiers

PMID37980801
PMCPMC11494610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.