ArticleInsights into imaging2023
Association of sex-specific abdominal adipose tissue with WHO/ISUP grade in clear cell renal cell carcinoma.
Article in Insights into imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Preoperative prediction for early recurrence in patients with pancreatic ductal adenocarcinoma: combining radiomics and abdominal fat analysis.BMC medical imaging · 2025Article
- Artificial intelligence-based multimodal prediction for nuclear grading status and prognosis of clear cell renal cell carcinoma: a multicenter cohort study.International journal of surgery (London, England) · 2025Article
- Impact of body fat composition on liver iron overload severity in hemochromatosis: a retrospective MRI analysis.La Radiologia medica · 2025Article
- Prognostic significance of systemic immunoinflammatory biomarkers in patients with clear cell renal cell carcinoma: a retrospective multicenter analysis.Frontiers in immunology · 2025Article
- Body composition as a potential imaging biomarker for predicting the progression risk of chronic kidney disease.Insights into imaging · 2024Article
- Development of a CT-assessed adiposity nomogram for predicting outcome in localized ccRCC.Abdominal radiology (New York) · 2024Article
- Preoperative visceral fat index predicts the survival outcomes of patients with gastric cancer after surgery.Oncology letters · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesTo explore the association between computed tomography (CT)-measured sex-specific abdominal adipose tissue and the pathological grade of clear cell renal cell carcinoma (ccRCC).
methodsThis retrospective study comprised 560 patients (394 males and 166 females) with pathologically proven ccRCC (467 low- and 93 high-grade). Abdominal CT images were used to assess the adipose tissue in the subcutaneous, visceral, and intermuscular regions. Subcutaneous fat index (SFI), visceral fat index (VFI), intermuscular fat index (IFI), total fat index (TFI), and relative visceral adipose tissue (rVAT) were calculated. Univariate and multivariate logistic regression analyses were performed according to sex to identify the associations between fat-related parameters and pathological grade.
resultsIFI was significantly higher in high-grade ccRCC patients than in low-grade patients for both men and women. For male patients with high-grade tumors, the SFI, VFI, TFI, and rVAT were significantly lower, but not for female patients. In both univariate and multivariate studies, the IFI continued to be a reliable and independent predictor of high-grade ccRCC, regardless of sex.
conclusionsIntermuscular fat index proved to be a valuable biomarker for the pathological grade of ccRCC and could be used as a reliable independent predictor of high-grade ccRCC for both males and females. CRITICAL RELEVANCE STATEMENT: Sex-specific fat adipose tissue can be used as a new biomarker to provide a new dimension for renal tumor-related research and may provide new perspectives for personalized tumor management decision-making approaches. KEY POINTS: • There are sex differences in distribution of subcutaneous fat and visceral fat. • The SFI, VFI, TFI, and rVAT were significantly lower in high-grade ccRCC male patients, but not for female patients. • Intermuscular fat index can be used as a reliable independent predictor of high-grade ccRCC for both males and females.
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