Evidence map›Paper›PMID 37980518›Full record

ArticleBMC urology2023

The success rate of small renal mass core needle biopsy and its impact on lowering benign resection rate.

Haijuan Gao, Behdokht Nowroozizadeh, Joaquin Ponce Zepeda, Jaime Landman, Ted Farzaneh, Cary Johnson, Hirad Hosseini, Min Han

Open access · goldAbstract read
In one paragraph

Article in BMC urology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Management of Small Renal Masses: Literature and Guidelines Review.International braz j urol : official journal of the Brazilian Society of Urology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Haijuan GaoDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA, USA.
Behdokht NowroozizadehDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA, USA.
Joaquin Ponce ZepedaDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA, USA.
Jaime LandmanDepartment of Urology, University of California, Irvine, Orange, CA, USA.
Ted FarzanehDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA, USA.
Cary JohnsonDepartment of Pathology and Laboratory Medicine, University of California, Irvine, Orange, CA, USA.
Hirad HosseiniUniversity of Southern California, Los Angeles, CA, USA.
Min HanDepartment of Pathology, City of Hope Medical Center, 1500 E. Duarte Road, Duarte, CA, 91010, USA. minhan@coh.org.
University of California, Irvine · USCity Of Hope National Medical Center · USUniversity of Southern California · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

backgroundSmall renal mass (SRM) biopsy remains under-utilized due to stigma. Meanwhile, the alarmingly high benign findings in resected kidney masses highlight the need for improved preoperative diagnosis and patient selection.

methodsThe purpose of this study is to review the success rate of SRM biopsy and to evaluate its impact on patient management. A total of 168 percutaneous image-guided core needle biopsies (CNBs) of SRMs were retrieved at a tertiary academic center between 2015 and 2019. Subsequent treatment choices, side effects and outcomes were retrospectively reviewed.

resultsThe diagnostic rate of CNB was 86.9%. Benign neoplasms accounted for a significant portion (14.3%) of SRM. Renal cell carcinomas (RCCs) were the most common diagnoses (69.6%) as expected. In biopsy-resection correlation, the positive predictive value of CNB was 100%. Tumor typing and subtyping by CNB were highly accurate, 100% and 98.3% respectively. Nuclear grading for clear cell RCC was accurate in 83.8% cases. The CNB results had significant impact on treatment. Most patients with RCCs underwent either resection (54.1%) or ablation (33.9%), in contrast to observation in benign neoplasms (90.5%). Most importantly, the benign resection rate (3.2%) in this series was much lower than the national average.

conclusionCNB provided accurate diagnoses for the majority of SRMs and revealed benign diagnoses in a subset of clinically suspicious lesions. Employment of CNB in suspicious SRM may help avoid overtreatment for benign lesions.

Indexed as

Carcinoma, Renal CellKidney NeoplasmsBiopsy, Large-Core NeedleHumansImage-Guided BiopsyRetrospective StudiesCore Needle BiopsyRenal cell carcinomaRenal MassResection

Identifiers

PMID37980518
PMCPMC10657570
OpenAlexW4388791559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.