Evidence map›Paper›PMID 37980423›Full record

ArticleNature communications2023

Membrane potential accelerates sugar uptake by stabilizing the outward facing conformation of the Na/glucose symporter vSGLT.

Farha Khan, Matthias Elgeti, Samuel Grandfield, Aviv Paz, Fiona B Naughton, Frank V Marcoline, Thorsten Althoff, Natalia Ermolova, Ernest M Wright, Wayne L Hubbell and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Revisiting vSGLT: Non-Radioactive Characterization of the Vibrio NaInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Farha Khan *Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Matthias Elgeti *Stein Eye Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA. melgeti@ucla.edu.ORCID 0000-0002-0550-4852
Samuel GrandfieldDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-4512-6593
Aviv PazDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0003-0792-492X
Fiona B NaughtonDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA.
Frank V MarcolineDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA.ORCID 0000-0002-8842-5470
Thorsten AlthoffDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0001-5688-5328
Natalia ErmolovaDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Ernest M WrightDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.ORCID 0000-0002-1023-4391
Wayne L HubbellStein Eye Institute, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Michael GrabeDepartment of Pharmaceutical Chemistry, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA, 94158, USA. michael.grabe@ucsf.edu.ORCID 0000-0003-3509-5997
Jeff AbramsonDepartment of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. jabramson@mednet.ucla.edu.ORCID 0000-0003-0004-7426
University of California, Los Angeles · USUniversity of California, San Francisco · USHauptman-Woodward Medical Research Institute · USVan Andel Institute · US

Funding

Deciphering molecular details of cellular sugar transport and their roles in diseaseR35GM135175 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ABRAMSON, JEFFREY S · 2020 to 2024
$3.9M
Computational Studies of Sodium SymportersR01GM089740 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GRABE, MICHAEL · 2011 to 2020
$2.8M
Ion permeation, lipid flipping, and membrane remodeling by TMEM16 proteinsR01GM137109 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRABE, MICHAEL · 2021 to 2024
$1.4M
Exploring the Conformational Landscape of G Protein Coupled ReceptorsR01GM137081 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELGETI, AXEL PETER MATTHIAS · 2021 to 2022
$640k
NIGMS NIH HHS R01 GM089740NIGMS NIH HHS R01 GM137081NIGMS NIH HHS R01 GM137109NIGMS NIH HHS R35 GM135175
6 · The paper itself

Abstract

Sodium-dependent glucose transporters (SGLTs) couple a downhill Na

Indexed as

SymportersElectron Spin Resonance SpectroscopyGalactoseGlucoseMembrane PotentialsProtein ConformationSodiumSodium-Glucose Transport ProteinsSugarsGalactoseGlucoseSodiumSodium-Glucose Transport ProteinsSugarsSymporters

Identifiers

PMID37980423
PMCPMC10657379
OpenAlexW4388792351

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.