Evidence map›Paper›PMID 37980388›Full record

ArticleScientific reports2023

Survival following complete resection of neuroblastoma in novel orthotopic rat xenograft model.

ReidAnn E Sever, Lauren Taylor Rosenblum, Miguel Reyes-Múgica, W Barry Edwards, Marcus M Malek, Gary Kohanbash

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

ReidAnn E Sever *Department of Neurological Surgery, University of Pittsburgh, 530 45th Street, Pittsburgh, PA, 15201, USA.ORCID 0009-0007-7063-2600
Lauren Taylor Rosenblum *Department of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA.ORCID 0000-0002-5628-1652
Miguel Reyes-MúgicaDepartment of Pathology, UPMC Children's Hospital of Pittsburgh, One Children's Hospital Drive, 4401 Penn Ave, Pittsburgh, PA, 15224, USA.ORCID 0000-0001-5698-3702
W Barry EdwardsDepartment of Biochemistry, University of Missouri, 117 Schweitzer Hall, Columbia, MO, 65211, USA.
Marcus M MalekDepartment of Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA. marcus.malek@chp.edu.
Gary KohanbashDepartment of Neurological Surgery, University of Pittsburgh, 530 45th Street, Pittsburgh, PA, 15201, USA. gary.kohanbash2@chp.edu.ORCID 0000-0002-3953-8022
University of Pittsburgh · USChildren's Hospital of Pittsburgh · USUniversity of Missouri · US

Funding

Postdoctoral Research Training in Biotherapy of CancerT32CA113263 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Udai S Kammula · 2006 to 2026
$3.6M
Intraoperative dual-labeled molecular tracer to improve surgery on neuroblastomaR01CA277664 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Gary Kohanbash, Marcus M. Malek · 2023 to 2026
$2.3M
NCI NIH HHS R01 CA277664NCI NIH HHS T32 CA113263NIH HHS R01 CA277664NIH HHS T32CA113263
6 · The paper itself

Abstract

Neuroblastoma accounts for 15% of pediatric cancer deaths, despite multimodal therapy including surgical resection. Current neuroblastoma rodent models are insufficient for studying the impact of surgery and combination treatments, largely due to the small size of mouse models. Human neuroblastoma SK-N-BE(2) cells were injected into the left adrenal gland of 5-6-week-old RNU homozygous nude rats. Rats were either monitored by MRI until humane endpoint was reached or after 5 weeks underwent operative tumor resection, followed by monitoring for recurrence and survival. Following neuroblastoma cell implantation, the majority of tumors grew to greater than 5000 mm

Indexed as

NeuroblastomaAdrenal GlandsAnimalsChildDisease Models, AnimalHeterograftsHumanitiesHumansMiceRats

Identifiers

PMID37980388
PMCPMC10657433
OpenAlexW4388795940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.