ArticleNitric oxide : biology and chemistry2024
Mechanistic analysis of the photolytic decomposition of solid-state S-nitroso-N-acetylpenicillamine.
Article in Nitric oxide : biology and chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Smartphone-Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Network Silsesquioxane-Based Organogel/Silicone Composites for the Long-Lasting Delivery of Nitric Oxide.Molecules (Basel, Switzerland) · 2026Article
- Development of a light-induced gas phase nitric oxide generator and its use in killing biofilm bacteria in vitro and ex vivo.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Novel stable "sandwich" cyclodextrin inclusion of a lipophilic S-nitrosothiol for controlled delivery of nitric oxide.Materials & design · 2026Article
- Emerging strategies for nitric oxide production and their topical application as nanodressings to promote diabetic wound healing.Journal of nanobiotechnology · 2025Review
- Feasibility of controlled nitric oxide generationDalton transactions (Cambridge, England : 2003) · 2025Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
S-Nitroso-N-acetylpenicillamine (SNAP) is among the most common nitric oxide (NO)-donor molecules and its solid-state photolytic decomposition has potential for inhaled nitric oxide (iNO) therapy. The photochemical NO release kinetics and mechanism were investigated by exposing solid-state SNAP to a narrow-band LED as a function of nominal wavelength and intensity of incident light. The photolytic efficiency, decomposition products, and the photolytic pathways of the SNAP were examined. The maximum light penetration depth through the solid layer of SNAP was determined by an optical microscope and found to be within 100-200 μm, depending on the wavelength of light. The photolysis of solid-state SNAP to generate NO along with the stable thiyl (RS·) radical was confirmed using Electron Spin Resonance (ESR) spectroscopy. The fate of the RS· radical in the solid phase was studied both in the presence and absence of O
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