Evidence map›Paper›PMID 37979909›Full record

ArticleMicrovascular research2024

Cerebral arterioles express the laminin subunits α4 and α5 in conjunction with α6β4 integrin, but strongly downregulate laminin α4 during hypoxia-induced arteriogenic remodeling.

Arjun Sapkota, Sebok K Halder, Richard Milner

Open access · greenAbstract read
In one paragraph

Article in Microvascular research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Glycocalyx and basal lamina in neurological disorders.Matrix biology : journal of the International Society for Matrix Biology · 2026
    Review
  2. Review
  3. Brain vascular basement membrane: Comparison of human and mouse brain at the transcriptomic and proteomic levels.Matrix biology : journal of the International Society for Matrix Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Arjun SapkotaSan Diego Biomedical Research Institute, 3525 John Hopkins Court, Suite 200, San Diego, CA 92121, USA.
Sebok K HalderSan Diego Biomedical Research Institute, 3525 John Hopkins Court, Suite 200, San Diego, CA 92121, USA.
Richard MilnerSan Diego Biomedical Research Institute, 3525 John Hopkins Court, Suite 200, San Diego, CA 92121, USA. Electronic address: rmilner@sdbri.org.
San Diego Biomedical Research Institute · US

Funding

The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCIDRF1NS119477 · NINDS · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI MILNER, D. RICHARD · 2021 to 2021
$2.2M
A vasculo-protective role for beta4 integrin in neuroinflammationR01NS103966 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI MILNER, D. RICHARD · 2018 to 2022
$2.1M
The protective role of microglia in preventing hypoxic disruption of blood-brain barrier integrity and VCIDR01NS119477 · NINDS · SAN DIEGO BIOMEDICAL RESEARCH INSTITUTE · PI MILNER, D. RICHARD · 2024 to 2025
$1.4M
NINDS NIH HHS R01 NS103966NINDS NIH HHS R01 NS119477NINDS NIH HHS RF1 NS119477
6 · The paper itself

Abstract

Previous studies have shown that expression of the endothelial laminin receptor α6β4 integrin in the brain is uniquely restricted to arterioles. As exposure to chronic mild hypoxia (CMH, 8 % O

Indexed as

Integrin alpha6beta4Integrin beta4ArteriolesHumansHypoxiaLamininIntegrin alpha6beta4Integrin beta4LamininArteriogenesisBlood vesselsBrainChronic mild hypoxiaLamininα6β4 integrin

Identifiers

PMID37979909
PMCPMC10872476
OpenAlexW4388736328

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.