Evidence map›Paper›PMID 37979905›Full record

ArticleExperimental eye research2024

Characterization of neural damage and neuroinflammation in Pax6 small-eye mice.

James D Cole, John A McDaniel, Joelle Nilak, Ashley Ban, Carlos Rodriguez, Zuhaad Hameed, Marta Grannonico, Peter A Netland, Hu Yang, Ignacio Provencio and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Reduction of lens size in PAX6-related aniridia.Experimental eye research · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

James D ColeNeuroscience Graduate Program, University of Virginia, Charlottesville, VA, USA; Department of Biology, University of Virginia, Charlottesville, VA, USA.
John A McDanielDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Joelle NilakDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Ashley BanDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Carlos RodriguezDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Zuhaad HameedDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Marta GrannonicoDepartment of Biology, University of Virginia, Charlottesville, VA, USA.
Peter A NetlandDepartment of Ophthalmology, University of Virginia, Charlottesville, VA, USA.
Hu YangLinda and Bipin Doshi Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, USA.
Ignacio ProvencioDepartment of Biology, University of Virginia, Charlottesville, VA, USA; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA. Electronic address: provencio@virginia.edu.
Xiaorong LiuDepartment of Biology, University of Virginia, Charlottesville, VA, USA; Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA; Program in Fundamental Neuroscience, University of Virginia, Charlottesville, VA, USA; Department of Psychology, University of Virginia, Charlottesville, VA, USA. Electronic address: xl8n@virginia.edu.
University of Virginia · USMissouri University of Science and Technology · US

Funding

Modulating aqueous humor outflow with engineered nanoparticles for glaucomaR01EY035088 · NEI · MISSOURI UNIVERSITY OF SCIENCE & TECHNOLOGY · PI Xiaorong Liu, Hu Yang · 2023 to 2026
$2.0M
Investigating nanoscale neuronal damages in early glaucoma towards clinical optical detectionR01EY029121 · NEI · NORTHWESTERN UNIVERSITY · PI LIU, XIAORONG, ZHANG, HAO F · 2018 to 2021
$2.0M
NEI NIH HHS R01 EY029121NEI NIH HHS R01 EY035088
6 · The paper itself

Abstract

Aniridia is a panocular condition characterized by a partial or complete loss of the iris. It manifests various developmental deficits in both the anterior and posterior segments of the eye, leading to a progressive vision loss. The homeobox gene PAX6 plays an important role in ocular development and mutations of PAX6 have been the main causative factors for aniridia. In this study, we assessed how Pax6-haploinsufficiency affects retinal morphology and vision of Pax6

Indexed as

AniridiaMicrophthalmosAnimalsEye ProteinsHomeodomain ProteinsHumansMiceMice, Inbred C57BLNeuroinflammatory DiseasesPaired Box Transcription FactorsPAX6 Transcription FactorEye ProteinsHomeodomain ProteinsPaired Box Transcription FactorsPax6 protein, mousePAX6 Transcription Factor

Identifiers

PMID37979905
PMCPMC10843716
OpenAlexW4388736242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.