ArticleMolecular cell2023
EGFR promotes ALKBH5 nuclear retention to attenuate N6-methyladenosine and protect against ferroptosis in glioblastoma.
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Article in Molecular cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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56citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
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Who cites it
56 citing papers in PubMed, 57 citations in OpenAlex.
- Translational insights and clinical challenges of targeting cancer stem cells.Signal transduction and targeted therapy · 2026Review
- N 6 -methyladenosine modification regulates cell death in cognitive impairment.Neural regeneration research · 2026Article
- mNature reviews. Neuroscience · 2026Review
- CRM-1 Aggravates Stroke Injury by Promoting BANF1-Mediated Unfolded Protein Response Through Inducing Nuclear Export of ALKBH5.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Cryptotanshinone Targets Ferroptosis in Glioma via the EGFR/ROS Signaling Pathway.Neurochemical research · 2026Article
- Targeting Ferroptosis in Glioblastoma: Molecular Mechanisms, Tumor Microenvironment, and Therapeutic Opportunities.Cancers · 2026Review
- RNA methylation in cell death: mechanisms and clinical applications.Molecular cancer · 2026Review
- Red blood cell-derived extracellular vesicles enable cisplatin and cetuximab combined therapy against triple-negative breast cancer.Journal of nanobiotechnology · 2026Article
- Metal-dependent regulated cell death: Molecular architecture and translational frontiers.iMeta · 2026Review
- Translating ferroptosis into oncology: challenges, opportunities and future directions.Nature reviews. Clinical oncology · 2026Review
- Stress granules restrain ferroptosis by sequestering ferritin.Nature cell biology · 2026Article
- RNA modifications in cancer and their detection: a review.Japanese journal of clinical oncology · 2026Review
- The role of m6A modification in spermatogenic dysfunction.Molecular biology reports · 2026Review
- RNA modification-mediated multidimensional crosstalk: a novel perspective on gene expression regulation.Genome biology · 2026Review
- RNA modifications and cancer ferroptosis.Cancer cell international · 2026Review
- METTL16-mediated mJournal of experimental & clinical cancer research : CR · 2026Article
- Ferroptosis in Glioblastoma and Neuroblastoma: Molecular Mechanisms and Novel Therapeutic Strategies.Current issues in molecular biology · 2026Review
- Emerging Dual Roles of ALKBH5 in Ischemia-reperfusion Injury: Mechanisms and Therapeutic Implications.Cell biochemistry and biophysics · 2026Review
- Article
- Atlas-Guided Nanocarrier Strategies Targeting Spatial NTRK2/MAPK Signaling in EGFR-TKI-Resistant Niches of Esophageal Squamous Cell Carcinoma.Pharmaceutics · 2026Review
Corrections and comments
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Authors and funding
15 authors at 11 institutions in 3 countries.
Deguan LvUPMC Hillman Cancer Center and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Cuiqing ZhongUPMC Hillman Cancer Center and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Deobrat DixitSanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Kailin YangDepartment of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH 44195, USA.
Qiulian WuUPMC Hillman Cancer Center and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Bhaskar GoduguDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Briana C PragerDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Guofeng ZhaoHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Xiuxing WangSchool of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Qi XieInstitute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, Zhejiang 310024, China.
Shideng BaoDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Chuan HeDepartment of Chemistry and Institute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
Dieter Henrik HeilandDepartment of Neurosurgery, Medical Center - University of Freiburg, Freiburg, Germany.
Michael G RosenfeldHoward Hughes Medical Institute, Department and School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
Jeremy N RichUPMC Hillman Cancer Center and Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA. Electronic address: drjeremyrich@gmail.com.
UPMC Hillman Cancer Center · USHoward Hughes Medical Institute · USUniversity of Pittsburgh · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USMassachusetts General Hospital · USNanjing Medical University · CNSanford Burnham Prebys Medical Discovery Institute · USUniversity of Chicago · USUniversity of Freiburg · DEWestlake University · CN
Funding
Dynamic Complexity of Brain Tumor Stem Cells (R35CA197718)R35CA197718 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICH, JEREMY N · 2015 to 2021
$6.4MMetabolic Regulation of Glioblastoma EpitranscriptomicsR01CA268634 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sameer Agnihotri, JEREMY N RICH · 2022 to 2026
$2.9MTargeting the Circadian Rhythm in Glioblastoma Stem Cells (R01CA238662)R01CA238662 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAY, STEVE A, RICH, JEREMY N · 2020 to 2024
$2.8MComputational Genomic Epidemiology of Cancer (CoGEC) Training ProgramT32CA094186 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Thomas Louis LaFramboise, Rong Xu · 2017 to 2026
$2.6MTargeting extracellular signaling-regulated kinase 5 (ERK5) in brain tumors and their microenvironmentR01NS115831 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AGNIHOTRI, SAMEER · 2020 to 2024
$1.8MDual Targeting of Brain Tumor Initiating Cells through Inhibition of BMI1 and EZH2 (R01NS103434)R01NS103434 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICH, JEREMY N · 2017 to 2021
$1.7MNCI NIH HHS R01 CA238662NCI NIH HHS R01 CA268634NCI NIH HHS R35 CA197718NCI NIH HHS T32 CA094186NINDS NIH HHS R01 NS103434NINDS NIH HHS R01 NS115831
Abstract
Growth factor receptors rank among the most important oncogenic pathways, but pharmacologic inhibitors often demonstrate limited benefit as monotherapy. Here, we show that epidermal growth factor receptor (EGFR) signaling repressed N
Indexed as
AlkB Homolog 5, RNA DemethylaseErbB ReceptorsFerroptosisGlioblastomaAdenosineHumansRNA, MessengerAdenosineALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseEGFR protein, humanErbB ReceptorsRNA, MessengerALKBH5cancer stem cellEGFRferroptosisGCLMglioblastomaglioblastoma stem cellm(6)ASRCYTHDF2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.