ArticleNeuron2024
Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation.
Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 52 citations in OpenAlex.
- Outcomes From Use of the Fédération International de Football Association (FIFA) 11⁺ Program With and Without Transcranial Direct Current Stimulation in 60 Male High School Soccer Players.Medical science monitor : international medical journal of experimental and clinical research · 2026Trial
- Mismatch negativity matures in adolescence and without sensitivity to microglial depletion.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Region- and Layer-Specific Glutamatergic Synapse Development in the Nascent Cortical Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Adolescent prefrontal and amygdala molecular signatures of perinatal morphine versus buprenorphine exposure in mice.Neurotoxicology · 2026Article
- Retrosplenial cortical reorganization during late adolescence introduces instability of contextual memory circuits.PLoS biology · 2026Article
- Alcohol or Stress Exposure During Late Adolescence Impairs Risk Assessment Later in Life, Disrupting the Ethological Structure of Behavior in Mice.Alcohol, clinical & experimental research · 2026Article
- Early-life stress impairs development of functional interactions and neuronal activity within prefrontal-amygdala networks in vivo.Molecular psychiatry · 2026Article
- Executive Functioning as a Mediator Between Digital Media Exposure and Communication Outcomes in Children and Adolescents.Journal of Intelligence · 2026Article
- Population-level encoding of task information is stronger in the adolescent compared to adult frontal cortex.Developmental cognitive neuroscience · 2026Article
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- A neuron type-specific microexon in Ank3/ankyrin-G modulates calcium activity and neuronal excitability.Nature communications · 2026Article
- Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition.Frontiers in psychiatry · 2026Review
- Neurotoxicity of heavy metals across the lifespan: The beneficial role of nutrition from fetus to the elderly.Advances in neurotoxicology · 2026Article
- Mapping prefrontal afferents along development.Frontiers in neuroscience · 2026Article
- Investigating hierarchical critical periods in human neurodevelopment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- A neuron type-specific microexon inbioRxiv : the preprint server for biology · 2025Article
- Neonatal microglia replacement in mice modulates seizure severity in adulthood.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Too sweet to be savory: how fructose elicits microglia-driven disturbance of neurodevelopment.Cell research · 2025Article
- Mismatch negativity develops in adolescence and independently of microglia.bioRxiv : the preprint server for biology · 2025Article
- Retrosplenial Cortical Reorganization During Late Adolescence Introduces Instability of Episodic Memory Circuits.Research square · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most cognitive functions involving the prefrontal cortex emerge during late development. Increasing evidence links this delayed maturation to the protracted timeline of prefrontal development, which likely does not reach full maturity before the end of adolescence. However, the underlying mechanisms that drive the emergence and fine-tuning of cognitive abilities during adolescence, caused by circuit wiring, are still unknown. Here, we continuously monitored prefrontal activity throughout the postnatal development of mice and showed that an initial activity increase was interrupted by an extensive microglia-mediated breakdown of activity, followed by the rewiring of circuit elements to achieve adult-like patterns and synchrony. Interfering with these processes during adolescence, but not adulthood, led to a long-lasting microglia-induced disruption of prefrontal activity and neuronal morphology and decreased cognitive abilities. These results identified a nonlinear reorganization of prefrontal circuits during adolescence and revealed its importance for adult network function and cognitive processing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.