ArticleDevelopmental cognitive neuroscience2023
Developmental coupling of brain iron and intrinsic activity in infants during the first 150 days.
Article in Developmental cognitive neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Hierarchical microstructural tissue growth of the gray and white matter of human visual cortex during the first year of life.Brain structure & function · 2026Article
- Human brain R2* transitions across birth from the womb to early infancy.Communications biology · 2025Article
- Whole Brain MRI Assessment of Age and Sex-Related R2* Changes in the Human Fetal Brain.Human brain mapping · 2025Article
- Nervonic acid in infant nutrition: a forward-looking approach to enhancing neurodevelopmental outcomes.Frontiers in nutrition · 2025Review
- Trajectories of human brain functional connectome maturation across the birth transition.PLoS biology · 2024Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Brain iron is vital for core neurodevelopmental processes including myelination and neurotransmitter synthesis and, accordingly, iron accumulates in the brain with age. However, little is known about the association between brain iron and neural functioning and how they evolve with age in early infancy. This study investigated brain iron in 48 healthy infants (22 females) aged 64.00 ± 33.28 days by estimating R2 * relaxometry from multi-echo functional MRI (fMRI). Linked independent component analysis was performed to examine the association between iron deposition and spontaneous neural activity, as measured by the amplitude of low frequency fluctuations (ALFF) by interrogating shared component loadings across modalities. Further, findings were validated in an independent dataset (n = 45, 24 females, 77.93 ± 26.18 days). The analysis revealed developmental coupling between the global R2 * and ALFF within the default mode network (DMN). Furthermore, we observed that this coupling effect significantly increased with age (r = 0.78, p = 9.2e-11). Our results highlight the importance of iron-neural coupling during early development and suggest that the neural maturation of the DMN may correspond to growth in distributed brain iron.
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Registered trials
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