Evidence map›Paper›PMID 37979218›Full record

Trial reportBehaviour research and therapy2023

What good are positive emotions for treatment? A replication test of whether trait positive emotionality predicts response to exposure therapy for social anxiety disorder.

Charles T Taylor, David Rosenfield, Sheila M Dowd, Christina D Dutcher, Stefan G Hofmann, Michael W Otto, Mark H Pollack, Jasper A J Smits

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Behaviour research and therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02066792 (Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02066792 early_phase1completednot on this map

Dose Timing of D-Cycloserine to Augment CBT for Social Anxiety Disorder

TypeinterventionalSponsorJasper A. SmitsRan2014 to 2018Enrolled152ConditionsSocial Anxiety DisorderArmsD-Cycloserine, Placebo, Cognitive Behavioral Therapy
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Charles T TaylorDepartment of Psychiatry, University of California, 9500 Gilman Drive (Mail code 0855) La Jolla, San Diego, CA, 92093-0855, United States. Electronic address: c1taylor@health.ucsd.edu.
David RosenfieldDepartment of Psychology, Southern Methodist University, United States.
Sheila M DowdDepartment of Psychiatry & Behavioral Sciences, Rush University Medical Center, United States.
Christina D DutcherDepartment of Psychology and Institute for Mental Health Research, University of Texas at Austin, United States.
Stefan G HofmannDepartment of Clinical Psychology, Philipps-University Marburg, Germany.
Michael W OttoDepartment of Psychological and Brain Sciences, Boston University, United States.
Mark H PollackSage Therapeutics, United States.
Jasper A J SmitsDepartment of Psychology and Institute for Mental Health Research, University of Texas at Austin, United States.
Texas Research Institute · USBoston University · USPhilipps University of Marburg · DERush University Medical Center · USSage Therapeutics (United States) · USSouthern Methodist University · USUniversity of California, San Diego · US

Funding

Connectomes Related to Anxiety and Depression in AdolescentsU01MH108168 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIELI, JOHN, WHITFIELD-GABRIELI, SUSAN · 2015 to 2019
$4.6M
Neural Markers of Treatment Mechanisms and Prediction of Treatment Outcomes in Social AnxietyR01MH128377 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DANIEL G DILLON, JOHN GABRIELI · 2022 to 2026
$4.3M
Novel Behavioral Intervention to Target Social Reward Sensitivity and AttachmentR33MH113769 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TAYLOR, CHARLES · 2020 to 2022
$2.2M
2/3-Dose Timing of D-cycloserine to Augment CBT for Social Anxiety DisorderR34MH099311 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HOFMANN, STEFAN G. · 2014 to 2016
$737k
Dose Timing of D-cycloserine to Augment CBT for Social Anxiety DisorderR34MH099309 · NIMH · RUSH UNIVERSITY MEDICAL CENTER · PI POLLACK, MARK H · 2014 to 2016
$698k
3/3-Dose Timing of D-cycloserine to Augment CBT for Social Anxiety DisorderR34MH099318 · NIMH · UNIVERSITY OF TEXAS AT AUSTIN · PI SMITS, JASPER · 2014 to 2016
$695k
NIMH NIH HHS R01 MH128377NIMH NIH HHS R33 MH113769NIMH NIH HHS R34 MH099309NIMH NIH HHS R34 MH099311NIMH NIH HHS R34 MH099318NIMH NIH HHS U01 MH108168
6 · The paper itself

Abstract

backgroundPositive valence emotions serve functions that may facilitate response to exposure therapy - they encourage approach behavior, diminish perceived threat reactivity, and enhance assimilation of new information in memory. Few studies have examined whether positive emotions predict exposure therapy success and extant findings are mixed.

methodsWe conducted a secondary analysis of an exposure therapy trial for social anxiety disorder to test the hypothesis that patients endorsing higher trait positive emotions at baseline would display the greatest treatment response. N = 152 participants enrolled in a randomized controlled trial of d-cycloserine augmentation completed five sessions of group exposure therapy. Pre-treatment positive emotionality was assessed using the NEO Five-Factor Inventory. Social anxiety symptoms were assessed throughout treatment by blinded evaluators using the Liebowitz Social Anxiety Scale.

resultsAccounting for baseline symptom severity, multilevel growth curve models revealed that patients with higher pre-treatment positive emotionality displayed faster social anxiety symptom reductions and lower scores at 3-month follow-up. This predictive effect remained significant after controlling for baseline depression and extraversion (without the positive emotionality facet).

conclusionsThese findings add to emerging evidence suggesting that explicitly targeting and enhancing positive emotions during exposure to perceived threat may improve treatment outcomes for anxiety and fear-based disorders.

trial registrationClinicalTrials.gov: NCT02066792https://clinicaltrials.gov/ct2/show/NCT02066792.

Indexed as

Implosive TherapyPhobia, SocialAnxietyAnxiety DisordersFearHumansTreatment OutcomeExposure therapyPositive emotionPredictionRandomized controlled trialSocial anxiety disorder

Identifiers

PMID37979218
PMCPMC10862259
OpenAlexW4388599241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.