Evidence map›Paper›PMID 37979173›Full record

ArticleCell reports2023

40-Hz optogenetic stimulation rescues functional synaptic plasticity after stroke.

Cong Wang, Caixia Lin, Yue Zhao, Montana Samantzis, Petra Sedlak, Pankaj Sah, Matilde Balbi

Abstract read
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In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  5. Article
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  7. Brain-Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety-Like Behaviors in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  8. Review
  9. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Cong WangQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, Australia; Engineering Research Centre of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai 201203, China.
Caixia LinQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, Australia.
Yue ZhaoDepartments of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Centre, Shanghai 200032, China; Institute of Thoracic Oncology, Fudan University, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Montana SamantzisQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, Australia.
Petra SedlakQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, Australia.
Pankaj SahQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, Australia.
Matilde BalbiQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4067, Australia. Electronic address: m.balbi@uq.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evoked brain oscillations in the gamma range have been shown to assist in stroke recovery. However, the causal relationship between evoked oscillations and neuroprotection is not well understood. We have used optogenetic stimulation to investigate how evoked gamma oscillations modulate cortical dynamics in the acute phase after stroke. Our results reveal that stimulation at 40 Hz drives activity in interneurons at the stimulation frequency and phase-locked activity in principal neurons at a lower frequency, leading to increased cross-frequency coupling. In addition, 40-Hz stimulation after stroke enhances interregional communication. These effects are observed up to 24 h after stimulation. Our stimulation protocol also rescues functional synaptic plasticity 24 h after stroke and leads to an upregulation of plasticity genes and a downregulation of cell death genes. Together these results suggest that restoration of cortical dynamics may confer neuroprotection after stroke.

Indexed as

OptogeneticsStrokeHumansInterneuronsNeuronal PlasticityNeuronsbrain oscillationsCP: Neurosciencecross-frequency couplingfunctional plasticityinterneuronsinterregional communicationoptogeneticstroke

Identifiers

PMID37979173

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.