Evidence map›Paper›PMID 37979070›Full record

ArticleBiological trace element research2024

The Role of Histone H2B Acetylation Modification in Aluminum-Induced Cognitive Dysfunction.

Jie Gao, Wei Liu, Jing Pei, Jing Li, Niping Hao, Shuo Yang, Xiaoming Yang, Danfeng Zou, Kebin Xu, Lifeng Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Biological trace element research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jie Gao *Department of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Wei Liu *Department of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Jing Pei *Department of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Jing LiDepartment of Shenyang Maternity and Child Health Hospital, No. 41 Shenzhou Road, Shenhe District, Shenyang, Liaoning Province, 110034, People's Republic of China.
Niping HaoDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Shuo YangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Xiaoming YangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Danfeng ZouDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China.
Kebin XuDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China. xukebin@symc.edu.cn.
Lifeng ZhangDepartment of Maternal, Child and Adolescent Health, School of Public Health, Shenyang Medical College, No.146 Yellow River North Street, Shenyang, Liaoning Province, 110034, People's Republic of China. zgykdxzlf@163.com.
Shenyang Medical College · CNShenyang Maternity and Child Health Hospital

Funding

Initiated Research Foundation for the Doctoral Program of Science and Technology Department of Liaoning Province, China 201601226National Natural Science Foundation of China 81673226Natural Science Foundation for graduate students of Shenyang Medical College, China Y20180512Natural Science Foundation for Innovation and Entrepreneurship Training Program of Education Department of Liaoning Province, China 201710164000038Natural Science Foundation for undergraduate students of Shenyang Medical College, China 20179028, X202310164036Natural Science Foundation of Education Department of Liaoning Province, China L2015544, LJKZ1146Natural Science Foundation of Science and Technology Department of Shenyang City, China 17-231-1-44Natural Science Foundation of Shenyang Medical College, China 20153043The Science and Technology Project of Liaoning Providence, China 2015225025The Science and Technology Project of Shenyang, China F15-139-9-09
6 · The paper itself

Abstract

Aluminum (Al) is a low toxic trace element that can accumulate in the nervous system and induce cognitive disorders characterized by reduced learning and memory ability. Neuroepigenetic effects are structural changes in cellular function by the brain in response to environmental stimuli by altering the expression of specific genes and repressing normal cellular transcription, leading to abnormalities in a variety of biological processes within the nervous system and affecting neurobehavioral responses. One of the most important mechanisms of epigenetic control on chromatin shape is histone modification. In the present study, we established an offspring rat model of Al intoxication to investigate the changes in spatial learning and memory retention abilities and the relationship with histone H2B acetylation modification in rats exposed to different doses of Al over a long period of time. The results demonstrated that long-term AlCl

Indexed as

AluminumCognitive DysfunctionHistonesAcetylationAnimalsFemaleHippocampusMaleRatsRats, Sprague-DawleyAluminumHistonesAlCl3CBPCognitive dysfunctionHDAC3Histone acetylationHistone H2B

Identifiers

PMID37979070
OpenAlexW4388799108

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.