Evidence map›Paper›PMID 37978846›Full record

ArticleJournal of integrative bioinformatics2023

Reconstruction of the regulatory hypermethylation network controlling hepatocellular carcinoma development during hepatitis C viral infection.

Evgeniya A Antropova, Tamara M Khlebodarova, Pavel S Demenkov, Anastasiia R Volianskaia, Artur S Venzel, Nikita V Ivanisenko, Alexandr D Gavrilenko, Timofey V Ivanisenko, Anna V Adamovskaya, Polina M Revva and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of integrative bioinformatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. BGRS: bioinformatics of genome regulation and data integration.Journal of integrative bioinformatics · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Evgeniya A AntropovaInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0003-2158-3252
Tamara M KhlebodarovaInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.
Pavel S DemenkovInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0001-9433-8341
Anastasiia R VolianskaiaNovosibirsk State University, Novosibirsk, Russia.
Artur S VenzelInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-7419-5168
Nikita V IvanisenkoInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-0333-8117
Alexandr D GavrilenkoInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.
Timofey V IvanisenkoInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-0005-9155
Anna V AdamovskayaKurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Polina M RevvaKurchatov Genomic Center of the Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Nikolay A KolchanovInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0001-6800-8787
Inna N LavrikTranslational Inflammation Research, Medical Faculty, Otto von Guericke University Magdeburg, 39106 Magdeburg, Germany.ORCID https://orcid.org/0000-0002-9324-309X
Vladimir A IvanisenkoInstitute of Cytology and Genetics, Siberian Branch of RAS, Novosibirsk, Russia.ORCID https://orcid.org/0000-0002-1859-4631
Novosibirsk State University · RUInstitute of Cytology and Genetics · RUOtto-von-Guericke-Universität Magdeburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) has been associated with hepatitis C viral (HCV) infection as a potential risk factor. Nonetheless, the precise genetic regulatory mechanisms triggered by the virus, leading to virus-induced hepatocarcinogenesis, remain unclear. We hypothesized that HCV proteins might modulate the activity of aberrantly methylated HCC genes through regulatory pathways. Virus-host regulatory pathways, interactions between proteins, gene expression, transport, and stability regulation, were reconstructed using the ANDSystem. Gene expression regulation was statistically significant. Gene network analysis identified four out of 70 HCC marker genes whose expression regulation by viral proteins may be associated with HCC:

Indexed as

Carcinoma, HepatocellularHepatitis CLiver NeoplasmsVirus DiseasesHepacivirusHistone-Lysine N-MethyltransferaseHumansViral Nonstructural ProteinsHistone-Lysine N-MethyltransferaseSMYD3 protein, humanViral Nonstructural ProteinsANDSystem softwaredifferentially expressed genesgene networksmarker genesregulatory pathways

Identifiers

PMID37978846
PMCPMC10757076
OpenAlexW4388800256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.