ArticleNature communications2023
Cobalt-catalyzed aminoalkylative carbonylation of alkenes toward direct synthesis of γ-amino acid derivatives and peptides.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
- Nickel-catalyzed ring-opening difunctionalization of methylenecyclobutanes via strain-release-enabled C-C activation.Nature communications · 2026Article
- Biomimetic sulfur-catalyzed carbonyl transfer enables the carbonylative difunctionalization of unactivated alkenes.Chemical science · 2026Article
- Acyl-oxyallenes as α,β-unsaturated ketone surrogates for Giese radical addition.Chemical science · 2026Article
- Recent Advances in Single-Electron-Transfer-Mediated Carbonylation.Chemical reviews · 2026Review
- Cobalt-Catalyzed Four-Component Carbonylative Synthesis of γ-Thioesters and γ-Thioamides from Thioethers and Ethylene.Organic letters · 2025Article
- Pincer-cobalt boosts divergent alkene carbonylation under tandem electro-thermo-catalysis.Nature communications · 2025Article
- Three-Component Synthesis of γ-Amino Esters with α-Quaternary Carbon Centers via NHC/Photoredox Dual Catalysis.Advanced synthesis & catalysis · 2025Article
- Iron-catalyzed three-component 1,2-azidoalkylation of conjugated dienesChemical science · 2025Article
- Single-Electron-Transfer-Mediated Carbonylation Reactions.Accounts of chemical research · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
γ-Amino acids and peptides analogues are common constituents of building blocks for numerous biologically active molecules, pharmaceuticals, and natural products. In particular, γ-amino acids are providing with better metabolic stability than α-amino acids. Herein we report a multicomponent carbonylation technology that combines readily available amides, alkenes, and the feedstock gas carbon monoxide to build architecturally complex and functionally diverse γ-amino acid derivatives in a single step by the implementation of radical relay catalysis. This transformation can also be used as a late-stage functionalization strategy to deliver complex, advanced γ-amino acid products for pharmaceutical and other areas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.