Evidence map›Paper›PMID 37977822›Full record

ArticleGenes & development2023

Characterization of the SF3B1-SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing.

Jian Zhang, Jindou Xie, Ji Huang, Xiangyang Liu, Ruihong Xu, Jonas Tholen, Wojciech P Galej, Liang Tong, James L Manley, Zhaoqi Liu

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Review
  3. BRD9 at the crossroads of splicing, chromatin remodeling, and hematopoiesis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2026
    Review
  4. Article
  5. Article
  6. Cancer-associated SF3B1 mutation K700E causes widespread changes in U2/branchpoint recognition without altering splicing.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Aberrant pre-mRNA processing in cancer.The Journal of experimental medicine · 2024
    Review
  12. Review
  13. Review
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jian Zhang *Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Jindou Xie *CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Ji HuangDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.ORCID 0000-0001-6547-9727
Xiangyang LiuDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.
Ruihong XuCAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Jonas TholenEuropean Molecular Biology Laboratory, 38042 Grenoble, France.
Wojciech P GalejEuropean Molecular Biology Laboratory, 38042 Grenoble, France.
Liang TongDepartment of Biological Sciences, Columbia University, New York, New York 10027, USA.
James L Manley *Department of Biological Sciences, Columbia University, New York, New York 10027, USA; jlm2@columbia.edu liuzq@big.ac.cn.
Zhaoqi Liu *CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China; jlm2@columbia.edu liuzq@big.ac.cn.
Columbia University · USChinese Academy of Sciences · CNEuropean Molecular Biology Laboratory · FR

Funding

Regulation of RNA processing: Mechanisms and ConsequencesR35GM118136 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI James L. Manley · 2016 to 2026
$8.9M
Structural and functional studies of mRNA processing, stability and quality controlR35GM118093 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI LIANG TONG · 2016 to 2026
$8.5M
NIGMS NIH HHS R35 GM118093NIGMS NIH HHS R35 GM118136
6 · The paper itself

Abstract

The spliceosomal gene

Indexed as

NeoplasmsSpliceosomesHumansMutationPhosphoproteinsRNA, MessengerRNA SplicingRNA Splicing FactorsPhosphoproteinsRNA, MessengerRNA Splicing FactorsSF3B1 protein, humanSUGP1 protein, humanAlphaFold-MultimerDHX15G-patchmyelodysplastic syndromesspliceosome mutations

Identifiers

PMID37977822
PMCPMC10760632
OpenAlexW4388757920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.