ArticleThe Journal of pharmacology and experimental therapeutics2024
Treatment of Sulfur Mustard Corneal Injury by Augmenting the DNA Damage Response (DDR): A Novel Approach.
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Article in The Journal of pharmacology and experimental therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3citing papers in PubMed
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3 citing papers in PubMed, 6 citations in OpenAlex.
- Current progress in research on ocular injury caused by exposure to vesicants.Progress in retinal and eye research · 2025Review
- Senescence and Stress Signaling Pathways in Corneal Cells After Nitrogen Mustard Injury.Cells · 2024Article
- Progress and Challenges in Developing Medical Countermeasures for Chemical, Biological, Radiological, and Nuclear Threat Agents.The Journal of pharmacology and experimental therapeutics · 2024Article
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Authors and funding
19 authors at 4 institutions in 1 country.
Robert ShalwitzInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.) rshalwitz@invirsa.com.
Tovah DayInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Anna Kotsakis RuehlmannInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).ORCID https://orcid.org/0000-0002-0440-1384
Lindsay JulioInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Shellaina GordonInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Adrianna VandeurenInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Marian NelsonInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Megan LymanInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Kyle KellyInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Amber AltvaterInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Celinia OndeckInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Sean O'BrienInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Tracey HamiltonInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Ryan L HansonInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Kayla WaymanInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Alexandrea MillerInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Isaiah ShalwitzInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Eric BatchelorInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).
Patrick McNuttInvirsa, Inc., Columbus, Ohio (R.S., A.K.R., A.M., I.S.); Department of Biology, Northeastern University, Boston, Massachusetts (T.D., L.J., S.G., A.V.); Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis, Minnesota (R.L.H., K.W., E.B.); United States Army Medical Research Institute for Chemical Defense, Gunpowder, Maryland (M.N., M.L., K.K., A.A., C.O., S.O., T.H., P.M.); and Wake Forest Institute for Regenerative Medicine, School of Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina (S.O., C.O., P.M.).ORCID https://orcid.org/0000-0002-5703-4565
MACOM (United States) · USNortheastern University · USForest Institute · USUnited States Army · US
Funding
Toxic Mechanisms of Vesicating Chemicals in the EyeR01EY034139 · NEI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNUTT, PATRICK MICHAEL · 2022 to 2024
$1.4MThe roles of p53 and MYC dynamics in regulating heterogeneous cell fate responses to genotoxic stressR01GM149666 · NIGMS · UNIVERSITY OF MINNESOTA · PI Eric Batchelor · 2023 to 2026
$1.3MThe Role of PARP3 in Telomere RegulationK01AG056554 · NIA · NORTHEASTERN UNIVERSITY · PI DAY, TOVAH · 2018 to 2022
$617kNEI NIH HHS R01 EY034139NIA NIH HHS K01 AG056554NIGMS NIH HHS R01 GM149666
Abstract
Sulfur mustard (SM) is a highly reactive organic chemical has been used as a chemical warfare agent and terrorist threat since World War I. The cornea is highly sensitive to SM toxicity and exposure to low vapor doses can cause incapacitating acute injuries. Exposure to higher doses can elicit persistent secondary keratopathies that cause reduced quality of life and impaired or lost vision. Despite a century of research, there are no specific treatments for acute or persistent ocular SM injuries. SM cytotoxicity emerges, in part, through DNA alkylation and double-strand breaks (DSBs). Because DSBs can naturally be repaired by DNA damage response pathways with low efficiency, we hypothesized that enhancing the homologous recombination pathway could pose a novel approach to mitigate SM injury. Here, we demonstrate that a dilithium salt of adenosine diphosphoribose (INV-102) increases protein levels of p53 and Sirtuin 6, upregulates transcription of BRCA1/2, enhances
Indexed as
Chemical Warfare AgentsCorneal InjuriesMustard GasAnimalsBRCA1 ProteinBRCA2 ProteinDNA DamageDNA RepairQuality of LifeRabbitsTumor Suppressor Protein p53BRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, humanChemical Warfare AgentsMustard GasTumor Suppressor Protein p53
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