Evidence map›Paper›PMID 37977787›Full record

ArticleAnalytica chimica acta2023

Application of surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging to pharmaceutical-loaded poly(ester urea) films.

Kayla Williams-Pavlantos, Natasha C Brigham-Stinson, Matthew L Becker, Chrys Wesdemiotis

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytica chimica acta, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kayla Williams-PavlantosDepartment of Chemistry, The University of Akron, Akron, OH, 44325, USA.
Natasha C Brigham-StinsonDepartment of Chemistry, Duke University, Durham, NC, 27708, USA.
Matthew L BeckerDepartment of Chemistry, Duke University, Durham, NC, 27708, USA; Thomas Lord Department of Mechanical Engineering & Materials Science, Duke University, Durham, NC, 27708, USA; Departments of Biomedical Engineering and Orthopedic Surgery, Duke University, Durham, NC, 27708, USA.
Chrys WesdemiotisDepartment of Chemistry, The University of Akron, Akron, OH, 44325, USA. Electronic address: wesdemiotis@uakron.edu.
Duke University · USUniversity of Akron · US

Funding

Non-Opioid Post-Operative Pain Management Using Bupivacaine-loaded Poly(ester urea) MeshR44GM140795 · NIGMS · 21MEDTECH LLC · PI YU, JIAYI · 2021 to 2021
$1.7M
NIGMS NIH HHS R44 GM140795
6 · The paper itself

Abstract

Polymer thin films are often used in transdermal patches as a method of continuous drug administration for patients with chronic illness. Understanding the drug segregation and distribution within these films is important for monitoring proper drug release over time. Surface-layer matrix-assisted laser desorption/ionization mass spectrometry imaging (SL-MALDI-MSI) is a unique analytical technique that provides an optical representation of chemical compositions that exist at the surface of polymeric materials. Solvent-free sublimation is employed for application of matrix to the sample surface, so that only molecules in direct contact with the matrix layer are detected. Here, these methodologies are utilized to visualize variations in drug concentration at both the air and substrate interface in pharmaceutical-loaded polymer films.

Indexed as

PolymersUreaHumansLasersPharmaceutical PreparationsSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationPharmaceutical PreparationsPolymersUreaMass spectrometry imagingPharmaceuticalsPoly(ester urea)Polymer thin filmsSurface layer analysis

Identifiers

PMID37977787
PMCPMC10657383
OpenAlexW4388000039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.