Evidence map›Paper›PMID 37977224›Full record

ArticleThe Journal of biological chemistry2023

Mapping immunological and host receptor binding determinants of SARS-CoV spike protein utilizing the Qubevirus platform.

Carrie Sanders, Aristide Dzelamonyuy, Augustin Ntemafack, Nadia Alatoom, Godwin Nchinda, Millie M Georgiadis, Alain Bopda Waffo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Carrie SandersDivision of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Disease, Center for Disease Control, Atlanta, Georgia, USA.
Aristide DzelamonyuyDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Augustin NtemafackDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Nadia AlatoomDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Godwin NchindaDepartment of Immunology, Laboratory of Vaccinology and Biobanking, Yaoundé, Cameroon.
Millie M GeorgiadisDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Alain Bopda WaffoDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: abopdaw@iu.edu.
Indiana University School of MedicineNational Center for Emerging and Zoonotic Infectious Diseases · US

Funding

Molecular Mechanism of the Parkinson's Disease-associated protein LRRK2R01AG075132 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI Quyen Quoc Hoang · 2022 to 2026
$2.6M
NIA NIH HHS R01 AG075132NIGMS NIH HHS SC3 GM132027
6 · The paper itself

Abstract

The motifs involved in tropism and immunological interactions of SARS-CoV spike (S) protein were investigated utilizing the Qubevirus platform. We showed that separately, 14 overlapping peptide fragments representing the S protein (F1-14 of 100 residues each) could be inserted into the C terminus of A1 on recombinant Qubevirus without affecting its viability. Additionally, recombinant phage expression resulted in the surface exposure of different engineered fragments in an accessible manner. The F6 from S

Indexed as

Angiotensin-Converting Enzyme 2Peptide LibrarySevere acute respiratory syndrome-related coronavirusSpike Glycoprotein, CoronavirusAntibodies, ViralEpitopesHumansProtein BindingAngiotensin-Converting Enzyme 2Antibodies, ViralEpitopesPeptide LibrarySpike Glycoprotein, Coronavirusspike glycoprotein, SARS-CoVA1 minor coat proteinanti-S antibodychimericQubevirusrhACE2SARS-covspike fragment

Identifiers

PMID37977224
PMCPMC10750099
OpenAlexW4388694728

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.