ArticleAmerican journal of respiratory cell and molecular biology2024
Epigenetic Reprogramming Drives Epithelial Disruption in Chronic Obstructive Pulmonary Disease.
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Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Unfolding Immune Dysregulation in COPD: Identification of a Three-Gene Signature and Functional Validation ofInternational journal of molecular sciences · 2026Article
- TRPC6 mediates goblet cell differentiation in COPD.Respiratory research · 2026Article
- CRISPR-engineered human lung organoids with a biomolecular condensate reporter enable mechanistic toxicity monitoring.Materials today. Bio · 2026Article
- New approaches to uncover COPD pathobiology and develop therapies.JCI insight · 2026Review
- Epigenomic study of the lower airway reveals COPD-associated methylation patterns and potential microbiota links.BMJ open respiratory research · 2025Article
- Review
- Low TET1 Expression Levels in COPD Are Associated with Airway and Blood Neutrophilia.medRxiv : the preprint server for health sciences · 2025Article
- Hypercapnic acidosis affectsFrontiers in cellular and infection microbiology · 2025Article
- Elevated Urotensin-II and TGF-β Levels in COPD: Biomarkers of Fibrosis and Airway Remodeling in Smokers.Medicina (Kaunas, Lithuania) · 2024Article
- Precision cut lung slices: an integrated ex vivo model for studying lung physiology, pharmacology, disease pathogenesis and drug discovery.Respiratory research · 2024Review
- Disinherit your Descendants by Rewriting the Chronic Pulmonary Obstructive Disease Epigenetic Script.American journal of respiratory cell and molecular biology · 2024Article
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Authors and funding
23 authors at 5 institutions in 1 country.
Bonnie H Yeung-LukDepartment of Environmental Health and Engineering and.
Ara WallyDepartment of Environmental Health and Engineering and.
Carter SwabyDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Sofia JaureguiDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Esther LeeDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Rachel ZhangDepartment of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.
Daniel ChenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Sean H LukDepartment of Environmental Health and Engineering and.
Nisha UpadyaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Ethan TiengDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Kai WilmsenDepartment of Environmental Health and Engineering and.
Ethan ShermanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Dheeksha SudhakarDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland.
Matthew LukDepartment of Environmental Health and Engineering and.
Abhishek Kumar ShrivastavDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California.
Shuo CaoDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California.
Baishakhi GhoshDepartment of Environmental Health and Engineering and.
Stephanie A ChristensonDivision of Pulmonary, Critical Care, Allergy and Sleep Medicine, University of California, San Francisco, San Francisco, California.
Yvonne J HuangDepartment of Medicine, University of Michigan, Ann Arbor, Michigan; and.ORCID 0000-0002-7497-6597
Victor E OrtegaDepartment of Pulmonary Medicine, Mayo Clinic, Phoenix, Arizona.
Shyam BiswalDepartment of Environmental Health and Engineering and.
Wan-Yee TangDepartment of Environmental Health and Engineering and.ORCID 0000-0002-0663-9820
Venkataramana K SidhayeDepartment of Environmental Health and Engineering and.ORCID 0000-0002-4506-8549
Johns Hopkins University · USUniversity of California, San Francisco · USMayo Clinic in Arizona · USUniversity of Michigan · USUniversity of Pittsburgh · US
Funding
Understanding Asthma EndotypesU19AI077439 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2008 to 2026
$41.1MSPIROMICS II: Biological underpinnings of COPD heterogeneity and progressionU01HL137880 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOODRUFF, PRESCOTT G · 2017 to 2021
$27.9MRole of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3MUnderstanding the Origins of Early COPDR01HL144718 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CURTIS, JEFFREY LOUIS, HAN, MEILAN K · 2020 to 2024
$11.3MSPIROMICS GIC SupportU24HL141762 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J, O'NEAL, WANDA K · 2018 to 2022
$7.2MInvestigating Effect of Air pollution and Host Defenses in SARS-CoV2 infectionU01ES026721 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI BISWAL, SHYAM, RAJAGOPALAN, SANJAY · 2016 to 2020
$3.8MSputum Microbial Markers of Type 2-Low AsthmaR01AI129958 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUANG, YVONNE JEAN · 2017 to 2021
$3.6MRole of E-cadherin in modulating airway epithelial function and parenchymal remodelingR01HL151107 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2020 to 2023
$2.4MActin-myosin contractility promotes the development of chronic bronchitisR01HL124099 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SIDHAYE, VENKATARAMANA K · 2017 to 2021
$2.1MMentoring Research in Precision Medicine for Lung DiseaseK24HL137013 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRESCOTT G WOODRUFF · 2017 to 2026
$1.2MLSM880 Laser-scanning Microscope with Airyscan ModuleS10OD023548 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2018 to 2018
$439kMitochondrial-epigenetic crosstalk in regulation of airway hyperresponsivenessR56HL158681 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TANG, WAN-YEE · 2022 to 2022
$388kNHLBI NIH HHS HHSN268200900013CNHLBI NIH HHS HHSN268200900014CNHLBI NIH HHS HHSN268200900015CNHLBI NIH HHS HHSN268200900016CNHLBI NIH HHS HHSN268200900017CNHLBI NIH HHS HHSN268200900018CNHLBI NIH HHS HHSN268200900019CNHLBI NIH HHS HHSN268200900020CNHLBI NIH HHS HLR01HL151107NHLBI NIH HHS K24 HL137013NHLBI NIH HHS P01 HL107202NHLBI NIH HHS R01 HL124099NHLBI NIH HHS R01HL124099NHLBI NIH HHS R01 HL144718NHLBI NIH HHS R01 HL151107NHLBI NIH HHS R56 HL158681NHLBI NIH HHS U01 HL137880NHLBI NIH HHS U24 HL141762NIAID NIH HHS U19 AI077439NIEHS NIH HHS 5U01ES026721NIEHS NIH HHS U01 ES026721NIGMS NIH HHS HHSN268200900013CNIGMS NIH HHS HHSN268200900014CNIGMS NIH HHS HHSN268200900015CNIGMS NIH HHS HHSN268200900016CNIGMS NIH HHS HHSN268200900017CNIGMS NIH HHS HHSN268200900018CNIGMS NIH HHS HHSN268200900019CNIGMS NIH HHS HHSN268200900020CNIGMS NIH HHS R01HL144718NIGMS NIH HHS R01HL182622NIGMS NIH HHS S10OD023548NIGMS NIH HHS U01HL137880NIGMS NIH HHS U24HL141762NIH HHS S10 OD023548
Abstract
Chronic obstructive pulmonary disease (COPD) remains a major public health challenge that contributes greatly to mortality and morbidity worldwide. Although it has long been recognized that the epithelium is altered in COPD, there has been little focus on targeting it to modify the disease course. Therefore, mechanisms that disrupt epithelial cell function in patients with COPD are poorly understood. In this study, we sought to determine whether epigenetic reprogramming of the cell-cell adhesion molecule E-cadherin, encoded by the
Indexed as
Pulmonary Disease, Chronic ObstructiveAnimalsCell DifferentiationDisease ProgressionDNA MethylationEpigenesis, GeneticHumansMiceMixed Function OxygenasesProto-Oncogene ProteinsMixed Function OxygenasesProto-Oncogene ProteinsTET1 protein, humanCDH1COPDDNA methylationE-cadherinepigenetic
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.