Evidence map›Paper›PMID 37976157›Full record

ArticleCell reports2023

MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.

Jiuzhou Huo, Vikram Prasad, Kelly M Grimes, Davy Vanhoutte, N Scott Blair, Suh-Chin Lin, Michael J Bround, Donald M Bers, Jeffery D Molkentin

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. The two faces of mitochondrial CaJournal of physiology and biochemistry · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Molecular Framework of the Onset and Progression of Skeletal Muscle Aging.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. The Role of N6-Methyladenosine in Mitochondrial Dysfunction and Pathology.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025
    Review
  13. Article
  14. MCU genetically altered mice suggest how mitochondrial CaTrends in endocrinology and metabolism: TEM · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. MCU-independent CaScientific reports · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jiuzhou HuoDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Vikram PrasadDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Kelly M GrimesDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Davy VanhoutteDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
N Scott BlairDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Suh-Chin LinDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Michael J BroundDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA.
Donald M BersDepartment of Pharmacology, University of California, Davis, Davis, CA 95616, USA.
Jeffery D MolkentinDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. Electronic address: jeff.molkentin@cchmc.org.
Cincinnati Children's Hospital Medical Center · USUniversity of California, Davis · US

Funding

Molecular examination of mitochondrial calcium controlR01HL132831 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BERS, DONALD M, MOLKENTIN, JEFFERY D · 2016 to 2024
$5.9M
Innate immune response signaling in cardiac injury healingR01HL156852 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MOLKENTIN, JEFFERY D · 2022 to 2025
$2.4M
NHLBI NIH HHS R01 HL132831NHLBI NIH HHS R01 HL156852
6 · The paper itself

Abstract

Mitochondria use the electron transport chain to generate high-energy phosphate from oxidative phosphorylation, a process also regulated by the mitochondrial Ca

Indexed as

CalciumMitochondriaAnimalsCalcium ChannelsFatty AcidsMembrane ProteinsMiceMitochondrial ProteinsMuscle, SkeletalCalciumCalcium ChannelsFatty AcidsMcub protein, mouseMembrane ProteinsMitochondrial ProteinsCP: Metabolismmetabolismmitochondriaobesityskeletal musclesubstrate utilization

Identifiers

PMID37976157
PMCPMC10842842
OpenAlexW4388745337

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.