ArticleJournal of fluorescence2025
Functionalized Graphene Quantum Dots (GQDs) based Label-Free Optical Fluorescence Sensor for CD59 Antigen Detection and Cellular Bioimaging.
Article in Journal of fluorescence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 5 citations in OpenAlex.
- A Comparative Study of Nitrogen Doped Carbon Dots Prepared from Linear Polyethyleneimine (L-PEI) and Branched Polyethyleneimine (B-PEI): Thermal, Optical, Biocompatibility, Sensor, Antibacterial, and Light-Induced Antibacterial Activity.Journal of fluorescence · 2025Article
- Fabrication and Characterization of Flexible pH Sensors Based on Pulsed Laser-Ablated Graphene/MoSNanomaterials (Basel, Switzerland) · 2025Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Cluster of differentiation (CD59), a cell surface glycoprotein, regulates the complement system to prevent immune damage. In cancer, altered CD59 expression allows tumors to evade immune surveillance, promote growth, and resist certain immunotherapies. Targeting CD59 could enhance cancer treatment strategies by boosting the immune response against tumors. Herein, we present a one-step synthesis of Polyethyleneimine (PEI) functionalized graphene quantum dots (Lf-GQDs) from weathered lemon leaf extract. The fabricated Lf-GQDs were successfully used for the quantitative detection of the cluster of CD59 antigen that is reported for its expression in different types of cancer. In this work, we utilized orientation-based attachment of CD59 antibody (Anti-CD59). Our findings reveal that, instead of using random serial addition of antigen or antibody, oriented conjugation saves accumulated concentration offering greater sensitivity and selectivity. The Anti-CD59@Lf-GQDs immunosensor was fabricated using the oriented conjugation of antibodies onto the Lf-GQDs surface. Besides, the fabricated immunosensor demonstrated detection of CD59 in the range of 0.01 to 40.0 ng mL
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