ReviewSpine deformity2024
Current biomechanical theories on the etiopathogenesis of idiopathic scoliosis.
Review in Spine deformity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Methodological exploration of stress-based finite element growth modeling for long-term brace treatment evaluation in adolescent idiopathic scoliosis.Medical & biological engineering & computing · 2026Article
- Vitamin-D status in sixty adolescents with idiopathic scoliosis: An observational study.Pakistan journal of medical sciences · 2026Article
- Fusion level selection in posterior hemivertebra resection for congenital scoliosis: clinical effect size driven feature selection and multi-criteria optimization decision model.Frontiers in medicine · 2026Article
- The impact of osteoporosis on spinal biomechanical stability in adolescent idiopathic scoliosis: a narrative review of finite element analysis and bone mineral density assessment.Frontiers in bioengineering and biotechnology · 2026Review
- Integrating intrinsic musculoskeletal pathology and genetics: Recent advances in unravelling the causative factors of adolescent idiopathic scoliosis.Bone reports · 2025Review
- A Retrospective Cross-Sectional Analysis of Abnormal Cervical Mechanics in Patients With Scoliosis.Cureus · 2025Article
- Management of adolescent scoliosis: a comprehensive review of etiology and rehabilitation.Frontiers in pediatrics · 2025Review
- Adolescent Idiopathic Scoliosis in Siblings Treated by Surgical Deformity Correction.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere is great controversy about the etiologic origin of adolescent idiopathic scoliosis. Multiple theories have been suggested, including metabolic aspects, endocrine dysfunction, neurological central abnormalities, genetic predisposition and epigenetic factors involved in the development of scoliosis. However, there has always been speculations based on human biomechanical behavior.
methodsIn this article, we performed a literature review on the biomechanical traits of human posture, and the proposed theories that explain the special characteristics present in idiopathic scoliosis.
resultsThe current theory on the etiopathogeneis of AIS suggests that dorsally directed shear loads acting on a preexisting axial plane rotation, in a posteriorly inclined sagittal plane of a growing patient, together with disc maturation, collagen quality at this phase of development and immaturity of proprioception, is the perfect scenario to spark rotational instability and create the three-dimensional deformity that defines idiopathic scoliosis.
conclusionThe unique spinal alignment of human bipedalism, gravity and muscle forces acting straight above the pelvis to preserve an upright balance, and the instability of the soft tissue in a period of growth development, is an appealing cocktail to try to explain the genesis of this condition in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.