Evidence map›Paper›PMID 37975947›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2023

Vaginal morbidity, sexual functioning, and health-related quality of life in cervical cancer survivors: a cross-sectional multicenter study (VAMOS).

Eline Naert, Alexander Decruyenaere, Renée Bultijnck, Emiel A De Jaeghere, Marjolein R P Orije, Rawand Salihi, Hans Verstraelen, Philippe Tummers, Hannelore G Denys, Katrien Vandecasteele

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 70% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 0 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 2 countries.

Eline NaertDepartment of Medical Oncology, Ghent University Hospital, 9000, Ghent, Belgium. eline.naert@uzgent.be.ORCID http://orcid.org/0000-0002-1508-7263
Alexander DecruyenaereDepartment of Medical Oncology, Ghent University Hospital, 9000, Ghent, Belgium.
Renée BultijnckCancer Research Institute Ghent (CRIG), Ghent, Belgium.
Emiel A De JaeghereDepartment of Medical Oncology, Ghent University Hospital, 9000, Ghent, Belgium.
Marjolein R P OrijeGynecological Pelvic Oncology Network (GYPON), Ghent, Belgium.
Rawand SalihiGynecological Pelvic Oncology Network (GYPON), Ghent, Belgium.
Hans Verstraelen *Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Philippe Tummers *Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Hannelore G Denys *Department of Medical Oncology, Ghent University Hospital, 9000, Ghent, Belgium.
Katrien Vandecasteele *Cancer Research Institute Ghent (CRIG), Ghent, Belgium.
Ghent University Hospital · BE

Funding

Fundamental Scientific Research/Fight Against Cancer Belgium G0F9319N
6 · The paper itself

Abstract

purposeTo compare sexual/vaginal functioning between early cervical cancer (ECC) and locally advanced cervical cancer (LACC) survivors.

methodsVAMOS was a multicenter, cross-sectional, questionnaire, noninferiority study including ECC patients treated with surgery and, if clinically indicated, adjuvant (chemo)radiotherapy and LACC patients treated with neoadjuvant (chemo)radiotherapy followed by surgery. Patient-reported outcomes (PROs) were assessed using the EORTC QLQ-C30, EORTC QLQ-CX24, and Female Sexual Functioning Index (FSFI) questionnaires. Clinical reported outcomes (ClinROs) consisted of vaginal morbidity scored according to the CTCAE v4.0 scoring system.

resultsOne hundred forty-three patients were included. Compared to ECC patients (n = 97), LACC patients (n = 46) were significantly less sexually active in the 4 weeks prior to completion of the questionnaires (65% vs. 41%; p = .005). The primary endpoint was not met: LACC patients reported a higher mean score (more problems) for sexual/vaginal functioning than ECC patients, with a non-clinically relevant mean difference of 6.38 ([95% CI: - 6.41, 19.17]; p = .570 for noninferiority). Regarding the secondary endpoints, the prevalence of sexual dysfunction between the two groups did not differ significantly (p = 0.124). Compared to ECC patients, LACC patients did not have significantly more vaginal morbidity (adjusted odds ratio [OR] 1.51 [95% CI: 0.22, 10.29]; p = .674). Moreover, there was poor agreement between any vaginal morbidity and sexual dysfunction (Cohen's kappa of 0.17).

conclusionCompared to ECC survivors, LACC survivors were significantly less sexually active and reported equivalent or worse sexual/vaginal functioning, although the proportion of patients with sexual dysfunction was similar. Clinical assessment of vaginal morbidity was poorly correlated with sexual dysfunction.

Indexed as

Cancer SurvivorsUterine Cervical NeoplasmsCross-Sectional StudiesFemaleHumansMorbidityQuality of LifeSurveys and QuestionnairesSurvivorsCancer survivorsCervical cancerFemale sexual functionHealth-related quality of lifeSexual dysfunctionSexuality

Identifiers

PMID37975947
OpenAlexW4388772833

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.