Evidence map›Paper›PMID 37975898›Full record

ReviewMedizinische Klinik, Intensivmedizin und Notfallmedizin2023

Challenges of assessing the burden of sepsis.

Carolin Fleischmann-Struzek, Kristina Rudd

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Molecular characterization of extended-spectrum β-lactamases-producing Escherichia coli isolated from patients with bacteremia.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  6. A two-step bioconjugation ofRSC chemical biology · 2026
    Article
  7. Observational
  8. Article
  9. Article
  10. Decoding Host-Pathogen Dynamics inAntibiotics (Basel, Switzerland) · 2026
    Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Observational
  18. Review
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Carolin Fleischmann-StruzekInstitute of Infectious Diseases and Infection Control, Jena University Hospital, Stoystr. 3, 07743, Jena, Germany. carolin.fleischmann@med.uni-jena.de.
Kristina RuddThe Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.

Funding

The Syndemic of Sepsis, Multimorbidity, Aging, and Low Healthcare Access and Quality in the United StatesK23GM141463 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RUDD, KRISTINA ELIZABETH · 2021 to 2025
$921k
NIGMS NIH HHS K23 GM141463
6 · The paper itself

Abstract

backgroundSepsis is one of the most frequent causes of death worldwide, but the recording of population-based epidemiology is challenging, which is why reliable data on sepsis incidence and mortality are only available in a few, mostly highly-resourced countries.

objectiveThe aim of this narrative review is to provide an overview of sepsis epidemiology worldwide and in Germany based on current literature, to identify challenges in this research area, and to give an outlook on future developments. MATERIALS AND

methodsSelective literature review. PubMed and Google Scholar were searched for current literature. The results were processed narratively.

resultsBased on modeling studies or meta-analyses of prospective studies, global annual sepsis incidence was found to be 276-678/100,000 persons. Case fatality ranged from 22.5 to 26.7%. However, current data sources have several limitations, as administrative data of selected individual countries-mostly with high income-were used as their basis. In these administrative data, sepsis is captured with limited validity. Prospective studies using clinical data often have limited comparability or lack population reference.

conclusionThere is a lack of reliable data sources and definitions to monitor the epidemiology of sepsis and collect reliable global estimates. Increased policy efforts and new scientific approaches are needed to improve our understanding of sepsis epidemiology, identify vulnerable populations, and develop and target effective interventions.

Indexed as

SepsisGermanyHumansIncidenceProspective StudiesEpidemiologyIncidenceMortalityReviewSeptic shock

Identifiers

PMID37975898
PMCPMC10733211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.