Evidence map›Paper›PMID 37975674›Full record

ArticleJournal of virology2023

Type I interferon signaling induces a delayed antiproliferative response in respiratory epithelial cells during SARS-CoV-2 infection.

Juliana Bragazzi Cunha, Kyle Leix, Emily J Sherman, Carmen Mirabelli, Tristan Frum, Charles J Zhang, Andrew A Kennedy, Adam S Lauring, Andrew W Tai, Jonathan Z Sexton and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Juliana Bragazzi CunhaDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Kyle LeixDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Emily J ShermanDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Carmen MirabelliDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Tristan FrumDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Charles J ZhangDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.
Andrew A KennedyDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Adam S LauringDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Andrew W TaiDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-6877-450X
Jonathan Z SextonDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-9244-5888
Jason R SpenceDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-5286-0924
Brian T EmmerDepartment of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-7365-1021
University of Michigan · US

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MERCHANT, JUANITA L. · 1986 to 2021
$22.5M
Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airwayR01HL166139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Spence · 2023 to 2026
$2.4M
How flaviviruses hijack a host transmembrane protein chaperone to promote viral infectionR01GM139823 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI TAI, ANDREW W. · 2021 to 2024
$1.4M
Cholesterol regulation by the cargo receptor SURF4K08HL148552 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMMER, BRIAN T · 2019 to 2023
$788k
NHLBI NIH HHS K08 HL148552NHLBI NIH HHS R01 HL166139NIDDK NIH HHS P30 DK034933NIGMS NIH HHS R01 GM139823
6 · The paper itself

Abstract

abstractDisease progression during SARS-CoV-2 infection is tightly linked to the fate of lung epithelial cells, with severe cases of COVID-19 characterized by direct injury of the alveolar epithelium and an impairment in its regeneration from progenitor cells. The molecular pathways that govern respiratory epithelial cell death and proliferation during SARS-CoV-2 infection, however, remain unclear. We now report a high-throughput CRISPR screen for host genetic modifiers of the survival and proliferation of SARS-CoV-2-infected Calu-3 respiratory epithelial cells. The top four genes identified in our screen encode components of the same type I interferon (IFN-I) signaling complex—

Indexed as

COVID-19Epithelial CellsInterferon Type ILungCell LineCell ProliferationHumansSARS-CoV-2Interferon Type Icell proliferationCRISPR screeninterferonSARS-CoV-2

Identifiers

PMID37975674
PMCPMC10734423
OpenAlexW4388762271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.