Evidence map›Paper›PMID 37975554›Full record

ArticleInternational forum of allergy & rhinology2024

Glutathione and bicarbonate nanoparticles improve mucociliary transport in cystic fibrosis epithelia.

Do Yeon Cho, Nicholas J Rivers, Dong-Jin Lim, Shaoyan Zhang, Daniel Skinner, Lydia Yang, Adithya J Menon, Olivia Jo Kelly, Martin P Jones, Brenton T Bicknell and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Treatment of lung diseasesMaterials today. Bio · 2025
    Review
  2. Article
  3. European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Do Yeon ChoDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-5173-8959
Nicholas J RiversDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-6097-2894
Dong-Jin LimDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Shaoyan ZhangDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Daniel SkinnerDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lydia YangDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Adithya J MenonDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Olivia Jo KellyDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Martin P JonesDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Brenton T BicknellDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jessica W GraysonDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0002-2131-8005
Elex HarrisGregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Steven M RoweDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Bradford A WoodworthDepartment of Otolaryngology-Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-3292-9167
University of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI David M. Bedwell · 2007 to 2026
$23.0M
Ivacaftor for Acquired CFTR Dysfunction in Chronic RhinosinusitisR01HL133006 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2016 to 2020
$1.7M
Dysbiosis of the Sinus Microbiota in Chronic RhinosinusitisK08AI146220 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2019 to 2021
$467k
Impact of mucin fermenting microbes on the virulence of Pseudomonas aeruginosa in chronic rhinosinusitisR21AI168894 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CHO, DO-YEON · 2022 to 2023
$408k
A Ginsenoside TMEM16A Potentiator for Cystic FibrosisR21AT012234 · NCCIH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WOODWORTH, BRADFORD ALAN · 2023 to 2024
$405k
National Institutes of Allergy and Infectious disease K08AI146220National Institutes of Allergy and Infectious disease R21AI168894National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute R01HL133006NCCIH NIH HHS R21AT01223NCCIH NIH HHS R21 AT012234NHLBI NIH HHS R01 HL133006NIAID NIH HHS K08 AI146220NIAID NIH HHS R21 AI168894NIDDK NIH HHS P30 DK072482NIDDK NIH HHS P30DK072482The Cystic Fibrosis Foundation Research 002481G221Triological Society Career Development Award, and Cystic Fibrosis Foundation K08 Boost Award CHO20A0-KB
6 · The paper itself

Abstract

introductionCystic fibrosis (CF) airway disease is characterized by thick mucus and impaired mucociliary transport (MCT). Loss of functional cystic fibrosis transmembrane receptor (CFTR) leads to acidification and oxidation of airway surface mucus. Replacing bicarbonate (HCO

methodsGSH/NaHCO

resultsSustained release of GSH and HCO

conclusionFindings suggest that GSH/NaHCO

Indexed as

BicarbonatesCystic FibrosisGlutathioneMucociliary ClearanceNanoparticlesAnimalsCells, CulturedEpithelial CellsHumansPolylactic Acid-Polyglycolic Acid CopolymerRabbitsRespiratory MucosaBicarbonatesGlutathionePolylactic Acid-Polyglycolic Acid Copolymerairway surface liquidbicarbonatechronic rhinosinusitischronic sinusitisciliary beat frequencycystic fibrosisglutathionemucociliary clearancemucociliary transportnanoparticleoptical coherence tomographypericiliary liquidsodium bicarbonate

Identifiers

PMID37975554
PMCPMC11098968
OpenAlexW4388783501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.