Evidence map›Paper›PMID 37975482›Full record

ArticleHeadache

Patient headache questionnaires can improve headache diagnosis and treatment in children.

Christina L Szperka, Stephanie Witzman, Svetlana Ostapenko, John T Farrar, Jesse Yenchih Hsu, Carrie P Malavolta, Janille D Bunney, Erin M Bange, Carlyn Patterson Gentile, Gerardo Velasquez and 10 more

Open access · greenAbstract read
In one paragraph

Article in Headache. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Headache trajectories in children and adolescents with new onset continuous headache.Cephalalgia : an international journal of headache · 2024
    Article
  5. Symptoms associated with headache in youth.Cephalalgia : an international journal of headache · 2023
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 1 country.

Christina L SzperkaDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4786-8889
Stephanie WitzmanChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Svetlana OstapenkoChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
John T FarrarDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8656-5157
Jesse Yenchih HsuDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1522-6534
Carrie P MalavoltaChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Janille D BunneyChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Erin M BangeMemorial Sloane Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-0000-6093
Carlyn Patterson GentileDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-4996-2457
Gerardo VelasquezUCSF School of Medicine, San Francisco, California, USA.
Blanca Marquez de PradoChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0009-0005-5350-3853
Mahgenn CosicoChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-5640-7473
Meyeon LeeChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Pamela Pojomovsky McDonnellDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Marisa S PrelackDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Madeline A ChadehumbeChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4952-8127
Donna J StephensonDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Elizabeth A KichulaDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Scott C TomaineChildren's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Andrew D HersheyDepartment of Pediatrics, Cincinnati Children's Hospital and University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0002-1598-7536
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · USCincinnati Children's Hospital Medical Center · USMemorial Sloan Kettering Cancer Center · USUniversity of California, San Francisco · US

Funding

Trigeminovascular sensitization in post-traumatic headache: electrophysiologic and blood biomarkers in youthK23NS124986 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Carlyn Anne Patterson Gentile · 2022 to 2026
$1.0M
Occipital Nerve Blocks for Acute Treatment of Pediatric MigraineK23NS102521 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI SZPERKA, CHRISTINA LYNCH · 2018 to 2022
$940k
NIH HHS K23 NS102521NIH HHS K23NS124986NINDS NIH HHS K23 NS102521NINDS NIH HHS K23 NS124986
6 · The paper itself

Abstract

objectiveTo examine trends in diagnosis of headache and migraine in a large pediatric neurology cohort, and test whether an electronic health record (EHR)-integrated headache questionnaire can increase specificity of diagnosis and likelihood of prescribing migraine treatment.

backgroundUnder-diagnosis of migraine contributes to the burden of disease. As we founded our Pediatric Headache Program in 2013, we recognized that the proportion of patients with headache who were given a diagnosis of migraine was much lower than expected.

methodsWe developed a patient headache questionnaire, initially on paper (2013-2014), then in an electronic database (2014-2016), and finally integrated into our electronic health record (pilot: 2016, full: May 2017). We compared diagnoses and prescribed treatments for new patients who were given a headache diagnosis, looking at trends in the proportion of patients given specific diagnoses (migraine, etc.) versus the non-specific diagnosis, "headache." Next, we conducted a prospective cohort study to test for association between provider use of the form and the presence of a specific diagnosis, then for an association between specific diagnosis and prescription of migraine treatment.

resultsBetween July 2011 and December 2022 the proportion of new headache patients who were given a diagnosis of migraine increased 9.7% and non-specific headache diagnoses decreased 21.0%. In the EHR cohort (June 2017-December 2022, n = 15,122), use of the provider form increased the rate of specific diagnosis to 87.2% (1839/2109) compared to 75.5% (5708/7560) without a patient questionnaire, nearly doubling the odds of making a specific diagnosis (odds ratio [OR] 1.90, 95% confidence interval [CI]: 1.65-2.19). Compared to those given only a non-specific headache diagnosis who were prescribed a migraine therapy 53.7% (1766/3286) of the time, 75.3% (8914/11836) of those given a specific diagnosis received a migraine therapy, more than doubling the odds of prescription (OR 2.39, 95% CI: 2.20-2.60).

conclusionsInterventions to improve specificity of diagnosis were effective and led to increased rates of prescription of migraine treatments. These results have been sustained over several years. This headache questionnaire was adapted into the Foundation system of EpicCare, so it is broadly available as a clinical and research tool for institutions that use this EHR software.

Indexed as

Migraine DisordersNeurologyChildHeadacheHumansProspective StudiesSurveys and Questionnairesdiagnosiselectronic health recordmigrainepediatric

Identifiers

PMID37975482
PMCPMC10836822
OpenAlexW4388783222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.