Evidence map›Paper›PMID 37975322›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2023

Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy.

Vladimir V Burmistrov, Christophe Morisseau, Dmitry V Danilov, Boris P Gladkikh, Vladimir S D'yachenko, Nikolay A Zefirov, Olga N Zefirova, Gennady M Butov, Bruce D Hammock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 10 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Vladimir V BurmistrovVolgograd State Technical University, Volgograd, Russia.
Christophe MorisseauDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, USA.
Dmitry V DanilovVolgograd State Technical University, Volgograd, Russia.
Boris P GladkikhVolgograd State Technical University, Volgograd, Russia.
Vladimir S D'yachenkoVolgograd State Technical University, Volgograd, Russia.
Nikolay A ZefirovDepartment of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.
Olga N ZefirovaDepartment of Chemistry, M. V. Lomonosov Moscow State University, Moscow, Russia.
Gennady M ButovVolgograd State Technical University, Volgograd, Russia.
Bruce D HammockDepartment of Entomology and Nematology, and Comprehensive Cancer Center, University of California, Davis, CA, USA.
Volgograd State Technical University · RUUniversity of California, Davis · USLomonosov Moscow State University · RUMoscow State University · TJ

Funding

Supplement for bioactive lipids as effectors and indicators of the deleterious effects of human healthR35ES030443 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MORISSEAU, CHRISTOPHE HP · 2019 to 2025
$5.8M
NIEHS NIH HHS R35 ES030443
6 · The paper itself

Abstract

Series of 1,3-disubstituted ureas and diadamantyl disubstituted diureas with fluorinated and chlorinated adamantane residues were shown to inhibit human soluble epoxide hydrolase (sEH) with inhibition potency ranging from 40 pM to 9.2 nM. The measured IC

Indexed as

ChlorineFluorineEpoxide HydrolasesHumansMolecular Dynamics SimulationUreaChlorineEpoxide HydrolasesFluorineUreaadamantanechlorine substituted adamantanesdiureafluorine substituted adamantanesSoluble epoxide hydrolase inhibitorsurea

Identifiers

PMID37975322
PMCPMC11003477
OpenAlexW4388765307

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.