Evidence map›Paper›PMID 37975220›Full record

ArticleOncology reports2024

Unravelling heterogeneous effects of cancer‑associated fibroblasts on poor prognosis markers in breast cancer EM‑G3 cell line:

Lukáš Urban, Štepán Novák, Matúš Čoma, Barbora Dvořánková, Lukáš Lacina, Jana Šáchová, Miluše Hradilová, Petra Svatoňová, Michal Kolář, Hynek Strnad and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Oncology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Lukáš Urban *Department of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, 040 11 Košice, Slovak Republic.
Štepán Novák *Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Matúš ČomaDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, 040 11 Košice, Slovak Republic.
Barbora DvořánkováInstitute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Lukáš LacinaInstitute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Jana ŠáchováLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Miluše HradilováLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Petra SvatoňováLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Michal KolářLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Hynek StrnadLaboratory of Genomics and Bioinformatics, Institute of Molecular Genetics, Czech Academy of Sciences, 142 20 Prague, Czech Republic.
Jana BřezinováCytogenetic Laboratory, Institute of Hematology and Blood Transfusion, 128 00 Prague, Czech Republic.
Karel SmetanaInstitute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Peter GálDepartment of Pharmacology, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, 040 11 Košice, Slovak Republic.
Pavol SzaboInstitute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic.
Charles University · CZCzech Academy of Sciences, Institute of Molecular Genetics · CZUniversity of Pavol Jozef Šafárik · SKCzech Academy of Sciences · CZInstitute of Haematology and Blood Transfusion · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is the most frequently diagnosed cancer in women worldwide. Although dramatically increased survival rates of early diagnosed cases have been observed, late diagnosed patients and metastatic cancer may still be considered fatal. The present study's main focus was on cancer‑associated fibroblasts (CAFs) which is an active component of the tumor microenvironment (TME) regulating the breast cancer ecosystem. Transcriptomic profiling and analysis of CAFs isolated from breast cancer skin metastasis, cutaneous basal cell carcinoma, and squamous cell carcinoma unravelled major gene candidates such as

Indexed as

Breast NeoplasmsCancer-Associated FibroblastsAntigens, SurfaceCell Line, TumorCutaneous Malignant MelanomaFemaleFibroblastsHumansKeratinsMCF-7 CellsMilk ProteinsPrognosisTranscriptomeTumor MicroenvironmentAntigens, SurfaceKeratinsMFGE8 protein, humanMilk Proteinsbreast cancercell differentiationepithelial‑mesenchymal interactionneutralizing antibodytumor microenvironment

Identifiers

PMID37975220
PMCPMC10688412
OpenAlexW4388701124

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.