Evidence map›Paper›PMID 37975184›Full record

ArticleNeurorehabilitation and neural repair2023

Multi-Site Identification and Generalization of Clusters of Walking Behaviors in Individuals With Chronic Stroke and Neurotypical Controls.

Natalia Sánchez, Nicolas Schweighofer, Sara J Mulroy, Ryan T Roemmich, Trisha M Kesar, Gelsy Torres-Oviedo, Beth E Fisher, James M Finley, Carolee J Winstein

Open access · greenAbstract read
In one paragraph

Article in Neurorehabilitation and neural repair, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Identification of Subtypes of Post-Stroke and Neurotypical Gait Behaviors Using Neural Network Analysis of Gait Cycle Kinematics.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
    Article
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Natalia SánchezDepartment of Physical Therapy, Chapman University, Irvine, CA, USA.ORCID 0000-0002-6467-1781
Nicolas SchweighoferDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.
Sara J MulroyDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.
Ryan T RoemmichCenter for Movement Studies, Kennedy Krieger Institute, Baltimore, MD, USA.ORCID 0000-0003-0797-6455
Trisha M KesarDepartment of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Gelsy Torres-OviedoDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Beth E FisherDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0002-9219-197X
James M FinleyDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0003-2679-2221
Carolee J WinsteinDivision of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.ORCID 0000-0001-9789-4626
University of Southern California · USEmory University · USKennedy Krieger Institute · USUniversity of Pittsburgh · US

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Stewart H Mostofsky · 2020 to 2026
$9.9M
Mentored Career DevelopmentKL2TR001854 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Elizabeth Rhea Erwin Burner, Amy Elizabeth West · 2016 to 2026
$9.0M
Technique Development CoreP2CHD065702 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI OTTENBACHER, KENNETH J. · 2015 to 2019
$5.2M
Center for Rehabilitation Research Using Large DatasetsR24HD065702 · NICHD · UNIVERSITY OF TEXAS MED BR GALVESTON · PI OTTENBACHER, KENNETH J. · 2010 to 2014
$4.0M
Biomechanical and neural mechanisms of post-stroke gait trainingR01HD095975 · NICHD · EMORY UNIVERSITY · PI KESAR, TRISHA · 2019 to 2024
$2.9M
Toward a Mechanistic Understanding of Optimization Principles Underlying Hemiparetic GaitR01HD091184 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FINLEY, JAMES M. · 2018 to 2022
$1.5M
A computational approach for understanding locomotor learning post-strokeK01NS092785 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TORRES-OVIEDO, GELSY · 2016 to 2018
$673k
Leveraging energetics to improve gait rehabilitation after strokeR21AG059184 · NIA · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI ROEMMICH, RYAN THOMAS · 2018 to 2019
$445k
Innovative Biofeedback Interface for Enhancing Stroke Gait RehabilitationR21HD095138 · NICHD · EMORY UNIVERSITY · PI KESAR, TRISHA · 2018 to 2019
$427k
Fast training promotes recovery of arm movements post-stroke via cerebellar-mediated anticipatory feedforward controlR21NS120274 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SCHWEIGHOFER, NICOLAS · 2020 to 2020
$422k
Determining the effects of increased demands for voluntary adjustments on the neuromuscular control of walking post-strokeR03HD107630 · NICHD · CHAPMAN UNIVERSITY · PI SANCHEZ, NATALIA · 2023 to 2024
$294k
A precision medicine approach to identify walking phenotypes and rehabilitation targets after injuryR03TR004248 · NCATS · CHAPMAN UNIVERSITY · PI SANCHEZ, NATALIA · 2022 to 2023
$137k
NCATS NIH HHS KL2 TR001854NCATS NIH HHS R03 TR004248NIA NIH HHS R21 AG059184NICHD NIH HHS P2C HD065702NICHD NIH HHS P50 HD103538NICHD NIH HHS R01 HD091184NICHD NIH HHS R01 HD095975NICHD NIH HHS R03 HD107630NICHD NIH HHS R21 HD095138NICHD NIH HHS R24 HD065702NINDS NIH HHS K01 NS092785NINDS NIH HHS R21 NS120274
6 · The paper itself

Abstract

backgroundWalking patterns in stroke survivors are highly heterogeneous, which poses a challenge in systematizing treatment prescriptions for walking rehabilitation interventions.

objectivesWe used bilateral spatiotemporal and force data during walking to create a multi-site research sample to: (1) identify clusters of walking behaviors in people post-stroke and neurotypical controls and (2) determine the generalizability of these walking clusters across different research sites. We hypothesized that participants post-stroke will have different walking impairments resulting in different clusters of walking behaviors, which are also different from control participants.

methodsWe gathered data from 81 post-stroke participants across 4 research sites and collected data from 31 control participants. Using sparse

resultsWe identified 4 stroke clusters: a fast and asymmetric cluster, a moderate speed and asymmetric cluster, a slow cluster with frontal plane force asymmetries, and a slow and symmetric cluster. We also identified a moderate speed and symmetric gait cluster composed of controls and participants post-stroke. The moderate speed and asymmetric stroke cluster did not generalize across sites.

conclusionsAlthough post-stroke walking patterns are heterogenous, these patterns can be systematically classified into distinct clusters based on spatiotemporal and force data. Future interventions could target the key features that characterize each cluster to increase the efficacy of interventions to improve mobility in people post-stroke.

Indexed as

StrokeStroke RehabilitationBiomechanical PhenomenaGaitHumansWalkingWalking Speedclustersground reaction forcesspatiotemporal variablesstrokewalking impairment

Identifiers

PMID37975184
PMCPMC10872629
OpenAlexW4388774776

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.