Evidence map›Paper›PMID 37975152›Full record

ArticleCancer medicine2023

A novel nomogram based on body composition and nutritional indicators to predict the prognosis of patients with muscle-invasive bladder cancer undergoing radical cystectomy.

Xin Zhong, Yunzhe Pan, Kang Wu, Langkun Wang, Peng Dou, Ping Tan, Peng Zhang, Xiang Li

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In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin ZhongDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yunzhe PanDepartment of Urology, Chengdu Second People's Hospital, Chengdu, Sichuan, China.
Kang WuDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Langkun WangDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Peng DouDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Ping TanDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Peng ZhangDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Xiang LiDepartment of Urology, Institute of Urology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-8471-0015

Funding

the Science and Technology Program of Sichuan Science and Technology Department 2023YFS0315
6 · The paper itself

Abstract

objectiveTo investigate the prognostic significance of body composition and nutritional indicators in patients undergoing radical cystectomy with muscle-invasive bladder cancer (MIBC) and to develop a novel nomogram that accurately predicts overall survival (OS).

methodsFrom December 2010 to December 2020, we retrospectively collected clinical and pathological data from 373 MIBC patients who underwent radical cystectomy at our hospital. Preoperative computed tomography (CT) images were used to measure the skeletal muscle index (SMI), subcutaneous adipose index (SAI), visceral adipose index (VAI), skeletal muscle density (SMD), subcutaneous adipose density (SAD), visceral adipose density (VAD), and visceral adipose to subcutaneous adipose area ratio (VSR). The clinicopathological characteristics were evaluated using LASSO regression and multivariate Cox regression, and a nomogram was constructed to predict 1-, 3-, and 5-year overall survival. The concordance index (C-index), time-dependent receiver operating characteristic curves (t-ROC), calibration curve, and decision curve analysis (DCA) were used to assess the discriminative ability, calibration, and clinical practicality of the nomogram.

resultsMultivariate analyses demonstrated that pT stage, lymph node status, LVI, SMD, and prognostic nutritional index (PNI) are independent prognostic factors for OS. Additionally, a nomogram was created. The nomogram's C-index was 0.714 (95% CI: 0.695-0.733). The area under the t-ROC curve of 1-, 3-, and 5-year survival corresponding to the model was 0.726, 0.788, and 0.785, respectively. The calibration curve demonstrated excellent agreement between the predicted and observed outcomes. The DCA revealed that patients with MIBC could benefit from the nomogram.

conclusionBased on body composition and nutritional indicators, we developed a novel nomogram with excellent predictive accuracy and reliability for predicting the prognosis of MIBC patients undergoing RC.

Indexed as

NomogramsUrinary Bladder NeoplasmsBody CompositionCystectomyHumansMuscle, SkeletalPrognosisReproducibility of ResultsRetrospective Studiesbody compositionMIBCnomogramnutritional indicatorsprognosis

Identifiers

PMID37975152
PMCPMC10757150

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.