Evidence map›Paper›PMID 37975009›Full record

ReviewBiophysical reviews2023

Cyanoarylporphyrazine dyes: multimodal compounds for personalised photodynamic therapy.

N Yu Shilyagina, L N Shestakova, N N Peskova, S A Lermontova, T S Lyubova, L G Klapshina, I V Balalaeva

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biophysical reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

N Yu ShilyaginaInstitute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia.ORCID https://orcid.org/0000-0001-5766-6880
L N ShestakovaInstitute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia.ORCID https://orcid.org/0000-0003-3885-6085
N N PeskovaInstitute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia.ORCID https://orcid.org/0000-0002-8698-0083
S A LermontovaRazuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia.ORCID https://orcid.org/0000-0001-8366-3886
T S LyubovaRazuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia.ORCID https://orcid.org/0000-0003-0258-7514
L G KlapshinaRazuvaev Institute of Organometallic Chemistry, Russian Academy of Sciences, Tropinin str., 49, 603137 Nizhny Novgorod, Russia.ORCID https://orcid.org/0000-0002-2686-980X
I V BalalaevaInstitute of Biology and Biomedicine, Lobachevsky State University, Gagarin Ave., 23, 603022 Nizhny Novgorod, Russia.ORCID 0000-0002-3245-3907

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy is known as an effective primary and adjuvant anticancer treatment. Compounds with improved properties or additional modalities are still needed to create an 'ideal' photosensitizer. In this article, we review cyanoarylporphyrazine dyes for photodynamic (anticancer) therapy that we have synthesised to date. The review provides information on the chemistry of cyanoarylporphyrazines, photophysical properties, cellular uptake features and the use of various carriers for selective delivery of cyanoarylporphyrazines to the tumour. The potential of cyanoarylporphyrazines as photodynamic anti-tumour agents also has been evaluated. The most interesting feature of cyanoarylporphyrazines is the dependence of the fluorescence quantum yield and excited state lifetime on the viscosity of the medium, which makes it possible to use them as viscosity sensors in photodynamic therapy. In the future, we expect that the unique combination of photosensitizer and viscosity sensor properties of cyanoarylporphyrazines will provide a tool for dosimetry and tailoring treatment regimens in photodynamic therapy to the individual characteristics of each patient.

Indexed as

Fluorescent molecular rotorsPhotodynamic therapyPhotosensitiserPorphyrazine

Identifiers

PMID37975009
PMCPMC10643710

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.