Evidence map›Paper›PMID 37974963›Full record

ArticleRSC medicinal chemistry2023

Development of novel thiazolidine-2,4-dione derivatives as PPAR-γ agonists through design, synthesis, computational docking, MD simulation, and comprehensive

Mahendra Gowdru Srinivasa, Revanasiddappa B C, Ashwini Prabhu, Vinitha Rani, Sudeep D Ghate, Prashantha Kumar B R

Open access · greenAbstract read
In one paragraph

Article in RSC medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 12 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Mahendra Gowdru SrinivasaDepartment of Pharmaceutical Chemistry, Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS) Mangalore India revan@nitte.edu.in.
Revanasiddappa B CDepartment of Pharmaceutical Chemistry, Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS) Mangalore India revan@nitte.edu.in.ORCID https://orcid.org/0000-0001-6105-7025
Ashwini PrabhuYenepoya Research Centre, Yenepoya (Deemed to be University) Deralakatte Mangalore 575 018 Karnataka India.ORCID https://orcid.org/0000-0002-0580-1638
Vinitha RaniYenepoya Research Centre, Yenepoya (Deemed to be University) Deralakatte Mangalore 575 018 Karnataka India.
Sudeep D GhateCenter for Bioinformatics, Nitte (Deemed to be University) Deralakatte Mangalore Karnataka - 575 018 India.
Prashantha Kumar B RDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research Mysuru-570015 Karnataka India.ORCID https://orcid.org/0000-0001-9503-741X
Nitte University · INYenepoya University · INJSS Academy of Higher Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study was conducted to develop new novel 2,4-thiazolidinedione derivatives (3h-3j) as peroxisome proliferator-activated receptor-γ (PPAR-γ) modulators for antidiabetic activity. The objective was to overcome the adverse effects of existing thiazolidinediones while maintaining their pharmacological benefits. The synthesized compounds were elucidated based on FT-IR,

Identifiers

PMID37974963
PMCPMC10650958
OpenAlexW4387757268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.